ID   PACA_URAJA              Reviewed;          38 AA.
AC   P81039;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Pituitary adenylate cyclase-activating polypeptide;
DE            Short=PACAP;
OS   Uranoscopus japonicus (Japanese stargazer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Uranoscopiformes; Uranoscopidae; Uranoscopus.
OX   NCBI_TaxID=70848;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=9213367; DOI=10.1016/s0196-9781(97)00122-8;
RA   Matsuda K., Takei Y., Katoh J., Shioda S., Arimura A., Uchiyama M.;
RT   "Isolation and structural characterization of pituitary adenylate cyclase
RT   activating polypeptide (PACAP)-like peptide from the brain of a teleost,
RT   stargazer, Uranoscopus japonicus.";
RL   Peptides 18:723-727(1997).
CC   -!- FUNCTION: PACAP plays pivotal roles as a neurotransmitter and/or a
CC       neuromodulator.
CC   -!- FUNCTION: Stimulates adenylate cyclase in pituitary cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P81039; -.
DR   SMR; P81039; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..38
FT                   /note="Pituitary adenylate cyclase-activating polypeptide"
FT                   /id="PRO_0000044749"
FT   MOD_RES         38
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   38 AA;  4619 MW;  BFCDB19A870AF065 CRC64;
     HSDGIFTDSY SRYRKQMAVQ KYLAAVLGRR YRQRVRNK