ID   PACC1_BOVIN             Reviewed;         350 AA.
AC   Q2KHV2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Proton-activated chloride channel {ECO:0000250|UniProtKB:Q9H813};
DE            Short=PAC {ECO:0000250|UniProtKB:Q9H813};
DE   AltName: Full=Transmembrane protein 206 {ECO:0000305};
GN   Name=PACC1 {ECO:0000250|UniProtKB:Q9H813};
GN   Synonyms=TMEM206 {ECO:0000250|UniProtKB:Q9H813};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-activated chloride channel that mediates import of
CC       chloride ion in response to extracellular acidic pH. Involved in
CC       acidosis-induced cell death by mediating chloride influx and subsequent
CC       cell swelling. {ECO:0000250|UniProtKB:Q9H813}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
CC   -!- SIMILARITY: Belongs to the proton-activated chloride channel family.
CC       {ECO:0000305}.
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DR   EMBL; BC112871; AAI12872.1; -; mRNA.
DR   RefSeq; NP_001040045.1; NM_001046580.1.
DR   AlphaFoldDB; Q2KHV2; -.
DR   SMR; Q2KHV2; -.
DR   STRING; 9913.ENSBTAP00000055839; -.
DR   PaxDb; Q2KHV2; -.
DR   PRIDE; Q2KHV2; -.
DR   Ensembl; ENSBTAT00000001006; ENSBTAP00000001006; ENSBTAG00000000758.
DR   GeneID; 616392; -.
DR   KEGG; bta:616392; -.
DR   CTD; 55248; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000758; -.
DR   VGNC; VGNC:36028; PACC1.
DR   eggNOG; ENOG502QS5H; Eukaryota.
DR   GeneTree; ENSGT00390000017528; -.
DR   HOGENOM; CLU_068069_0_0_1; -.
DR   InParanoid; Q2KHV2; -.
DR   OMA; ITYMLFA; -.
DR   OrthoDB; 829411at2759; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000000758; Expressed in thymus and 103 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0061797; F:pH-gated chloride channel activity; ISS:UniProtKB.
DR   GO; GO:0006821; P:chloride transport; ISS:UniProtKB.
DR   InterPro; IPR029366; TMEM206.
DR   PANTHER; PTHR16087; PTHR16087; 1.
DR   Pfam; PF15122; TMEM206; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..350
FT                   /note="Proton-activated chloride channel"
FT                   /id="PRO_0000279470"
FT   TOPO_DOM        1..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..350
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   MOD_RES         9
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   MOD_RES         10
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D771"
FT   MOD_RES         14
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D771"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66H28"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  40135 MW;  E2B8E1BD147FDCF0 CRC64;
     MIRQELSTSY QELSEELDQV VENSEQADER DKETVKVHGP GILPALDSES ASSSIRFSKA
     CLKNVFSVLL IFIYLLLMAV AVFLVYQTIM DFREKLKHPV MSVSYKEVDR YDAPGIALYP
     GQAQLLSCKH YYEVIPPLRS PGQPGDVNCT TQRVNYTDPF SNQTLKSALI VRGPREVQKR
     ELVFLQFRLN QSSEDFSAID YLLFSSFQEF LQSPDRAGFM QACESAYSSW KFSGGFRTWV
     KMSLVETKEE DGREAVEFRQ ETSVVNYIDQ RPAAEKSAQL FFVVFEWKDP FIQKVQDIIT
     ANPWNTIALL CGAFLALFKA AEFAKLSVKW MIKIRRRYLK KRGQATNHIS