位置:首页 > 蛋白库 > PACC1_DANRE
PACC1_DANRE
ID   PACC1_DANRE             Reviewed;         298 AA.
AC   Q7SY31;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Proton-activated chloride channel {ECO:0000303|PubMed:31023925};
DE            Short=PAC {ECO:0000303|PubMed:31023925};
DE            Short=fPAC {ECO:0000303|PubMed:31023925};
DE   AltName: Full=Transmembrane protein 206 {ECO:0000305};
GN   Name=pacc1 {ECO:0000250|UniProtKB:Q9H813};
GN   Synonyms=tmem206 {ECO:0000250|UniProtKB:Q9H813};
GN   ORFNames=zgc:63579 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=31023925; DOI=10.1126/science.aav9739;
RA   Yang J., Chen J., Del Carmen Vitery M., Osei-Owusu J., Chu J., Yu H.,
RA   Sun S., Qiu Z.;
RT   "PAC, an evolutionarily conserved membrane protein, is a proton-activated
RT   chloride channel.";
RL   Science 364:395-399(2019).
CC   -!- FUNCTION: Proton-activated chloride channel that mediates import of
CC       chloride ion in response to extracellular acidic pH (PubMed:31023925).
CC       Displays channel activity with distinct kinetic properties compared to
CC       the human ortholog channel (PubMed:31023925).
CC       {ECO:0000269|PubMed:31023925}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
CC   -!- SIMILARITY: Belongs to the proton-activated chloride channel family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC055145; AAH55145.1; -; mRNA.
DR   AlphaFoldDB; Q7SY31; -.
DR   SMR; Q7SY31; -.
DR   STRING; 7955.ENSDARP00000129197; -.
DR   TCDB; 1.A.114.1.2; the proton-activated chloride channel (pacc) family.
DR   PaxDb; Q7SY31; -.
DR   PRIDE; Q7SY31; -.
DR   ZFIN; ZDB-GENE-040426-1173; pacc1.
DR   eggNOG; ENOG502QS5H; Eukaryota.
DR   InParanoid; Q7SY31; -.
DR   PhylomeDB; Q7SY31; -.
DR   PRO; PR:Q7SY31; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0061797; F:pH-gated chloride channel activity; IDA:UniProtKB.
DR   GO; GO:0006821; P:chloride transport; IDA:UniProtKB.
DR   InterPro; IPR029366; TMEM206.
DR   PANTHER; PTHR16087; PTHR16087; 1.
DR   Pfam; PF15122; TMEM206; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..298
FT                   /note="Proton-activated chloride channel"
FT                   /id="PRO_0000279475"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..245
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..298
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
SQ   SEQUENCE   298 AA;  34687 MW;  FDF913F608634FE3 CRC64;
     MPIGFNKACL KNVFTVILVL IYLALTAVAV FLAYQTISDF MDKLNHPVMS VSYKEVEEFA
     APGIVLFPGK AHLLSCMHHY HDNIPPLVAL ENLAKRECMK EEVIYHGPYS NQTEKRALVF
     RGPTDVRNRE LIFLQLSRNE TEEDFSAISY MIFAKFSDML ESSDKAAFMM DCERNYSMWT
     FSGGFRTWVK MSLVRTSGRR NESVEFRQES SVVKYIDKRP PLEQTNELFF IVFQWRDPFI
     QQVKDIVTAN PWNTIAILCG VFMALFKAAD FAKLSIKWMI RIRKRHIRAK MREMNQIS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024