PACC1_DANRE
ID PACC1_DANRE Reviewed; 298 AA.
AC Q7SY31;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Proton-activated chloride channel {ECO:0000303|PubMed:31023925};
DE Short=PAC {ECO:0000303|PubMed:31023925};
DE Short=fPAC {ECO:0000303|PubMed:31023925};
DE AltName: Full=Transmembrane protein 206 {ECO:0000305};
GN Name=pacc1 {ECO:0000250|UniProtKB:Q9H813};
GN Synonyms=tmem206 {ECO:0000250|UniProtKB:Q9H813};
GN ORFNames=zgc:63579 {ECO:0000303|Ref.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=31023925; DOI=10.1126/science.aav9739;
RA Yang J., Chen J., Del Carmen Vitery M., Osei-Owusu J., Chu J., Yu H.,
RA Sun S., Qiu Z.;
RT "PAC, an evolutionarily conserved membrane protein, is a proton-activated
RT chloride channel.";
RL Science 364:395-399(2019).
CC -!- FUNCTION: Proton-activated chloride channel that mediates import of
CC chloride ion in response to extracellular acidic pH (PubMed:31023925).
CC Displays channel activity with distinct kinetic properties compared to
CC the human ortholog channel (PubMed:31023925).
CC {ECO:0000269|PubMed:31023925}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
CC -!- SIMILARITY: Belongs to the proton-activated chloride channel family.
CC {ECO:0000305}.
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DR EMBL; BC055145; AAH55145.1; -; mRNA.
DR AlphaFoldDB; Q7SY31; -.
DR SMR; Q7SY31; -.
DR STRING; 7955.ENSDARP00000129197; -.
DR TCDB; 1.A.114.1.2; the proton-activated chloride channel (pacc) family.
DR PaxDb; Q7SY31; -.
DR PRIDE; Q7SY31; -.
DR ZFIN; ZDB-GENE-040426-1173; pacc1.
DR eggNOG; ENOG502QS5H; Eukaryota.
DR InParanoid; Q7SY31; -.
DR PhylomeDB; Q7SY31; -.
DR PRO; PR:Q7SY31; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0061797; F:pH-gated chloride channel activity; IDA:UniProtKB.
DR GO; GO:0006821; P:chloride transport; IDA:UniProtKB.
DR InterPro; IPR029366; TMEM206.
DR PANTHER; PTHR16087; PTHR16087; 1.
DR Pfam; PF15122; TMEM206; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..298
FT /note="Proton-activated chloride channel"
FT /id="PRO_0000279475"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H813"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H813"
SQ SEQUENCE 298 AA; 34687 MW; FDF913F608634FE3 CRC64;
MPIGFNKACL KNVFTVILVL IYLALTAVAV FLAYQTISDF MDKLNHPVMS VSYKEVEEFA
APGIVLFPGK AHLLSCMHHY HDNIPPLVAL ENLAKRECMK EEVIYHGPYS NQTEKRALVF
RGPTDVRNRE LIFLQLSRNE TEEDFSAISY MIFAKFSDML ESSDKAAFMM DCERNYSMWT
FSGGFRTWVK MSLVRTSGRR NESVEFRQES SVVKYIDKRP PLEQTNELFF IVFQWRDPFI
QQVKDIVTAN PWNTIAILCG VFMALFKAAD FAKLSIKWMI RIRKRHIRAK MREMNQIS