ID   PACC1_XENTR             Reviewed;         352 AA.
AC   Q0V9Z3;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Proton-activated chloride channel {ECO:0000250|UniProtKB:Q9H813};
DE            Short=PAC {ECO:0000250|UniProtKB:Q9H813};
DE   AltName: Full=Transmembrane protein 206 {ECO:0000305};
GN   Name=pacc1 {ECO:0000250|UniProtKB:Q9H813};
GN   Synonyms=tmem206 {ECO:0000250|UniProtKB:Q9H813};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-activated chloride channel that mediates import of
CC       chloride ion in response to extracellular acidic pH.
CC       {ECO:0000250|UniProtKB:Q7SY31}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
CC   -!- SIMILARITY: Belongs to the proton-activated chloride channel family.
CC       {ECO:0000305}.
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DR   EMBL; BC121336; AAI21337.1; -; mRNA.
DR   RefSeq; NP_001072297.1; NM_001078829.1.
DR   AlphaFoldDB; Q0V9Z3; -.
DR   SMR; Q0V9Z3; -.
DR   STRING; 8364.ENSXETP00000029401; -.
DR   GeneID; 779750; -.
DR   KEGG; xtr:779750; -.
DR   CTD; 55248; -.
DR   Xenbase; XB-GENE-985604; pacc1.
DR   eggNOG; ENOG502QS5H; Eukaryota.
DR   HOGENOM; CLU_068069_0_0_1; -.
DR   InParanoid; Q0V9Z3; -.
DR   OrthoDB; 829411at2759; -.
DR   PhylomeDB; Q0V9Z3; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014356; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q0V9Z3; baseline.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0061797; F:pH-gated chloride channel activity; ISS:UniProtKB.
DR   GO; GO:0006821; P:chloride transport; ISS:UniProtKB.
DR   InterPro; IPR029366; TMEM206.
DR   PANTHER; PTHR16087; PTHR16087; 1.
DR   Pfam; PF15122; TMEM206; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..352
FT                   /note="Proton-activated chloride channel"
FT                   /id="PRO_0000279477"
FT   TOPO_DOM        1..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..299
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        321..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H813"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..37
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  40977 MW;  9D56DF30F3BD778B CRC64;
     MEAIRKELSR SYQELNEEAE PVAIDPEEAE DEEKEQEEAA SAVAPDRDSD RSSPPVRFSR
     TCLKNFFSVL LILVYLLLMG VAVFLVYQTI TDFRDKLKHP VMSVSYKEVN MYDAPGIALY
     PGKARLLSCE HHWYDHIPPL KDPGQPGENT CVTQDISYID PYTNKTMKHA LIVQGPRDVR
     RRELVFLQFH LNETKQDFSA IDYLLFSSYE AFLKSHDQVK FMQDCESSFS SWKFSGGFRT
     WVKMSLVKTK EEDGSQSVEF RQETSVVNFI DRRETPDKGD QLFFVVFEWK DPYIQEIQDI
     ITANPWSMIA LLCSVFLVLF KAADFAKLSV KWMIKVRRRH LKKRARELNH IS