ID   PACC_ACRCH              Reviewed;         621 AA.
AC   Q96X49;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Acremonium chrysogenum (Cephalosporium acremonium).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreales incertae sedis; Acremonium.
OX   NCBI_TaxID=5044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DNA-BINDING.
RX   PubMed=11405634; DOI=10.1007/s004380000439;
RA   Schmitt E.K., Kempken R., Kueck U.;
RT   "Functional analysis of promotor sequences of cephalosporin C biosynthesis
RT   genes from Acremonium chrysogenum: specific DNA-protein interactions and
RT   characterization of the transcription factor PACC.";
RL   Mol. Genet. Genomics 265:508-518(2001).
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes. Specifically recognizes and binds the consensus
CC       sequence 5'-GCCARG-3'. {ECO:0000269|PubMed:11405634}.
CC   -!- SUBUNIT: Binds to DNA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AJ251521; CAC38840.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q96X49; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Cytoplasm; Metal-binding; Nucleus; Repeat; Repressor; Zinc; Zinc-finger.
FT   CHAIN           1..621
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046827"
FT   ZN_FING         53..78
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         89..113
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         119..141
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           445..448
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           613..616
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        7..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        501..526
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..603
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   621 AA;  68151 MW;  FD8019400FD03DD1 CRC64;
     MSPPAPDAQP SSGSSSDNSN ADSKSTTPPP PSSTTSTTSA AAISAAVVPD DNLTCRWNAC
     NQKFPNPETL YDHICERHVG RKSTNNLNLT CQWNSCRTTT VKRDHITSHI RVHVPLKPHK
     CEFCGKSFKR PQDLKKHVKT HADDSVLVRP SQDNHNQGGM NYRPHLNKTP SYYDHNGQMR
     TQYQHHQPAH PNAYYAPQPS TNYGLYFNQP PLNNHQRTEH LGYGAPPGGY DRKRAFDMVD
     DFFSSAKRRE IDPSSYSQIG RSLLPLHGTL SIPSGPMPAT EQHYVPQPQH AGIAHAGPAP
     TQNPLAQQYY LPMPPNARTQ KDLVQIDNLL GQMQDTIYEN ANHATAGVQI HHGHDHYSGY
     RSSQSPPIAQ RGSPGGMPVG PDGYHQPVSA ATMASPLTAM SSTGTPAVTP PSSAVSYTSG
     HSPSPSAPAM SPQSRHSSTS GSVMYPSLPT SLPAVSQGFG QSTTTTLGPS FESNERRRYS
     GGMLQRARAA PPRSTDNHNH NHNHGASTPK APVSPALASP SSEVSDVSEA TREREEQYDR
     WLENMRVIES LREYVRGRLE RREYVEEQEN EHQGQGEAAR KERDGNPMDV DARSPRSPAR
     EQPGRPREGS SLYPILRMPG D