ID   PACC_ASPFU              Reviewed;         676 AA.
AC   Q4WY67; Q8X196;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC; ORFNames=AFUA_3G11970;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-167.
RA   Pocas-Fonseca M.J., Neves E.O., Azevedo M.O., Kubicek C.P.;
RT   "Putative PacC zinc finger-encoding region of Aspergillus fumigatus
RT   Fresenius.";
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92386.1; -; Genomic_DNA.
DR   EMBL; AF451286; AAL47849.1; -; Genomic_DNA.
DR   RefSeq; XP_754424.1; XM_749331.1.
DR   AlphaFoldDB; Q4WY67; -.
DR   STRING; 746128.CADAFUBP00003643; -.
DR   EnsemblFungi; EAL92386; EAL92386; AFUA_3G11970.
DR   GeneID; 3511803; -.
DR   KEGG; afm:AFUA_3G11970; -.
DR   VEuPathDB; FungiDB:Afu3g11970; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_012842_1_0_1; -.
DR   InParanoid; Q4WY67; -.
DR   OMA; QWGNCRT; -.
DR   OrthoDB; 507875at2759; -.
DR   PHI-base; PHI:3235; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:AspGD.
DR   GO; GO:0071469; P:cellular response to alkaline pH; IMP:AspGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..676
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046819"
FT   ZN_FING         80..105
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         116..140
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         146..168
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           459..462
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           660..663
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        384..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..444
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..532
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        99
FT                   /note="D -> E (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        101
FT                   /note="I -> V (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        147
FT                   /note="K -> R (in Ref. 2; AAL47849)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="T -> N (in Ref. 2; AAL47849)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   676 AA;  71949 MW;  22BA092EBC8D2B40 CRC64;
     MSEHQDTATN NNTTASPSAT AAPMPAPISQ EQPSSQPAAT TPAPVSTSTP PASVTATAAA
     ATAAVSAPQA NGTPPSDEQL SCLWQGCSEK CPSAEALYDH ICERHVGRKS TNNLNLTCQW
     GSCRTTTVKR DHITSHIRVH VPLKPHKCEF CGKAFKRPQD LKKHVKTHAD DSVLVRSPEP
     GARNPDMMFH GAGKGYAAAA HYFEPSLNAV PSQGYAHGAP QYYSSHPPHQ PSNPSYGNVY
     YALNHGHDGH ASYESKKRGY DALNEFFGDL KRRQFDLHSY AAVGQRLLGL QNLSLPILTG
     GPLPEYQPMP APVAVGGGYG PGGHGAPVYH LPPMSNIRTK NDLINIDQFL QQMQDTIYEN
     DDHVAAAGVA QPGAHYVHGG MSYRTTHSPP TQLPPSHAVA TTSASTSMSN PATHSPPTGT
     PALTPPSSAQ SYTSARSPIS ISSAHRVSPP HHDGGSGMYP RLPSTTMADS LAGGYPTASS
     AAPPSTLSGI FDDDRRRYTG GTLQRARPEE RRPSIQMDTS HDGKEDGERT PTGKARSSGS
     DSPVRISANL IDPALHSSSP SDAEAALRTA QAATEVADRA DSQWVEKVRL LEYLRSYIAS
     RLERGEYDSD SDDHASAAAS PVIKHDGHMD GVESSHKPIT AEETSAPPAA KAESNHGVMY
     PTLHGLDGDE DTKMHH