ID   PACC_ASPGI              Reviewed;         678 AA.
AC   Q5XL24;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Aspergillus giganteus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=5060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Meyer V.;
RT   "Putative transcription factor PacC of Aspergillus giganteus.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AY763122; AAV28549.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5XL24; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..678
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046820"
FT   ZN_FING         83..108
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         119..143
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         149..171
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           462..465
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           662..665
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        1..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        621..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  72618 MW;  F3E76B82ECFFAB2D CRC64;
     MSEHQDNNNN NTAATAASPS STVAPVPTPV PQEQLSSQLP APAAPAPVSA ATPVPSVTAT
     AAAATAAVAS PPMNGSPRPS EELSCLWQGC SEKCSSAEAL YEHICERHVG RKSTNNLNLT
     CQWGSCRTTT VKRDHITSHI RVHVPLKPHK CEFCGKAFKR PQDLKKHVKT HADDSVLVRS
     PEPGSRNPDM MFPGGGKGYA AAAHYFEPSL NPVPSQAYGH GAPQYYQAHP PPQPANPSYG
     NVYYALNHGH DGHASYESKK RGYDALNEFF GDLKRRQFDL HSYAAVGQRL LGLQNLSLPI
     LAGGPLPEYQ PMPAPVAVGG GYSPGGHGPP VYHLPPMSNV RTKNDLLNID QFLQQMQETI
     YENDDHVAAA GVAQPGAHYV HGGMSYRTTH SPPSQLPPSH ATATTSAATM MSHPATHSPS
     TGTPALTPPS SAQSYTSGRS PISMSSAHRV SPPHHDGGSG MYPRLPSATM ADSMTAGYPT
     TSSAAPPSTL GGIFDDDRRR YTGGTLQRAR PEERRLSVDM DIRQDGKEVG DRTPTGKEAG
     SQSASPVRIS ANLIDPALHS NSSSDAESAL RTAQAATEVA ERTDSQWVEK VRLLEYLRNY
     IASRLDRGEY DADARRALAR HSPEMRHDGH MEGVETSHTL TKPEEPAASP AIRSLSDDSV
     MYPTLRGLGG DEDTKMHS