ID   PACC_ASPPA              Reviewed;         662 AA.
AC   Q96UW0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Aspergillus parasiticus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=5067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 90816 / SK1;
RA   Pinero D., Keller N.P.;
RT   "Isolation and characterization of the Aspergillus parasiticus pacC gene.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AF408430; AAK98616.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q96UW0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..662
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046823"
FT   ZN_FING         68..93
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         104..128
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         134..156
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          595..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           450..453
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           646..649
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        376..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..625
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  70854 MW;  F6EE8740F410078B CRC64;
     MSEPQDTTSP STAAAPITAS TSQEQSQTQS PPQVSATTTS SVTATAAAAT AAVASPPVNG
     AARPTEELSC LWQGCSEKCP TPESLYEHVC ERHVGRKSTN NLNLTCQWGS CRTTTVKRDH
     ITSHIRVHVP LKLHKCDFCG KAFKRPQDLK KHVKTHADDS VLVRSPEPGS RNPDIMFGGN
     PAKGYATATH YFEPALNPVP SQGYAHGAPQ YYQAHHPPQP ANPSYGNVYY ALNHGHEAGH
     ASYESKKRGY DALNEFFGDL KRRQFDPNSY AAVGQRLLGL QSLSLPILSG GPLPEYQPMP
     APVAVGGGGY SPGGHPPAPA YHLPPMSNVR TKNDLINIDQ FLQQMQDTIY ENDDNVAAAG
     VAQPGAHYVH GGMSYRTTHS PPSQLPPSHA TATTSAGPMM ANPATHSPTG TPALTPPSSA
     QSYTSGRSPI SLPSTSRVSP PHHEGGSSMY PRLPSATMPD SMTAGYPTTS SAAPPSTLGG
     IFDHDDRRRY TGGTLQRARP EERHLPEPMD LSHDNKDDGE RTPPAKPRQA PSSPGRISAS
     LIDPALSGSA NEAETMRTAQ AATEVAERSD VQWVEKVRLI EYLRNYIASR LERGEYDGDS
     GMTRESRTPE AGPDGHMEGV ETEPVSHPAK SESPVKPEAG GDTVMYPTLR GVDEDGDSKM
     PN