ID   PACC_CANGA              Reviewed;         584 AA.
AC   Q6FV94;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=RIM101; OrderedLocusNames=CAGL0E03762g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including RIM101 itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; CR380951; CAG58769.1; -; Genomic_DNA.
DR   RefSeq; XP_445850.1; XM_445850.1.
DR   AlphaFoldDB; Q6FV94; -.
DR   STRING; 5478.XP_445850.1; -.
DR   EnsemblFungi; CAG58769; CAG58769; CAGL0E03762g.
DR   GeneID; 2887304; -.
DR   KEGG; cgr:CAGL0E03762g; -.
DR   CGD; CAL0128756; CAGL0E03762g.
DR   VEuPathDB; FungiDB:CAGL0E03762g; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_029652_0_0_1; -.
DR   InParanoid; Q6FV94; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..584
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046826"
FT   ZN_FING         153..178
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         189..213
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         219..241
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          385..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  67048 MW;  4411AE88C139D281 CRC64;
     MYGIFYAPEK LQIRRKDREK KKYLVSHTWI VKTPLPLISG QSYININKKT KKNSNIWEFR
     ILPETSNTSL NTAMHTMVKN GQQTPVLLGS KIEPRDSTSI KSLVNEPNTP TDMYHPKIKT
     EYDMTIKKES PTSTEPLKET TKDTSKDTPK ETLICKWSHC YREFQQAELL YHHLCQEHVG
     RKSQKNLQLK CQWDNCTSKT EKRDHMTSHL RVHVPLKPFA CSTCSKRFKR PQDLKKHLKI
     HLSDLGIDAP KKKRGPKVGS KRVNSKSFHK VSYDQVPAIG SASQPRFNHY APMQASQPVS
     YEHWVQMEMP HYTPVYSPAL AERVQAISAP TLYVQGFENR EPVVAATQFF TRLSTNMAYQ
     VPNIQNQHLY VPNYVGRPDN LYLHSTAHSS DNSVKTSSSS SPIETSVPTT HHTDNKRSPL
     PAIHYVPQSN IPLVHSHVQP HYSANEVRPL PSLSSISMVT PKYVIDQNLP KYNRTYDTFS
     TNQKSCADEE EEIYDSDVSD DEISDMMNKV NLSDKNANEE EYDSDEEDFI ATFKRVNILK
     DYAICTLLEE EYDTEDEPEP VLQPNVAESK SFDAHLMTFP EILI