PACC_CRYNJ
ID PACC_CRYNJ Reviewed; 917 AA.
AC P0CS62; Q55J93; Q5KCH0;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 46.
DE RecName: Full=pH-response transcription factor pacC/RIM101;
GN Name=RIM101; OrderedLocusNames=CNH00970;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Transcription factor that mediates regulation of both
CC acid- and alkaline-expressed genes in response to ambient pH. At
CC alkaline ambient pH, activates transcription of alkaline-expressed
CC genes (including RIM101 itself) and represses transcription of acid-
CC expressed genes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds to DNA. Interacts with RIM20, which binds to the YPX[LI]
CC motifs and is required for proteolytic processing (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR EMBL; AE017348; AAW44985.1; -; Genomic_DNA.
DR RefSeq; XP_572292.1; XM_572292.1.
DR AlphaFoldDB; P0CS62; -.
DR STRING; 5207.AAW44985; -.
DR PaxDb; P0CS62; -.
DR PRIDE; P0CS62; -.
DR EnsemblFungi; AAW44985; AAW44985; CNH00970.
DR GeneID; 3259088; -.
DR KEGG; cne:CNH00970; -.
DR VEuPathDB; FungiDB:CNH00970; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_317828_0_0_1; -.
DR InParanoid; P0CS62; -.
DR OMA; THLCETH; -.
DR OrthoDB; 475796at2759; -.
DR Proteomes; UP000002149; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:CACAO.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IMP:CACAO.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..917
FT /note="pH-response transcription factor pacC/RIM101"
FT /id="PRO_0000046830"
FT ZN_FING 67..92
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 103..127
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 133..155
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 873..914
FT /evidence="ECO:0000255"
FT MOTIF 494..497
FT /note="YPX[LI] motif"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 99165 MW; 378D1551A4DBA3B7 CRC64;
MAYPTLPPNL LSTPNTYSDS VSPTDPEPIT PELVSREPEK PAQKAAKTAM NNTSTASKPS
ESKGETLPCK WTGCSHISDS PDELYDHLCT VHVGRKSTNN LCLTCGWENC GTKCVKRDHI
TSHLRVHTPL KPHPCAVCGK TFKRPQDLKK HERIHTAEHH QLHKLSKAPT TADPEFNSRV
SLSSATRIDR PRSPLSTSLS PTSTSSHSLH SSSSPFDHLL ATGFHTDKSV SPTPSALALL
HKKQHEELAA YQQKEMLVLQ QLAFNQQQSQ AYAARLAAEP FGTGAGAKRG QADAFHDLLS
DVKKRKVEPV YDQDMIHRLN ALVPPSLPTS FPTLPSLGGY NQYQTFPSFN GYPSLPSLHT
SIYPTTAPQA QYSNQSPLPI PEIKTEADLA MFNEFMISLG RDAAANKAGP HPMTQSASGS
GASNGYSASN SGTPLSETSG GVEDLFNAEE LASLGLAGMP GISIHSGGSH NSNDESTHSL
SDASPPAVSF GGLYPSLDAM RNRTNSAPDV SALSGAARRP IAGLPRTSMG NAHNTSTNQS
TKPSYLSGMF GHSSSQQYDG TTHNYLHGLS NEHHNDYSHS ANNGATNAYA SFDSLARNKQ
SFPAATLAPK MFHNKVYRDV APLGTAVSKR ARESAERTNV EDSDREELYA DQESNHGYAV
SNERAREERT PKIPVRSLIA SIRTLSPSTA ADGEDDLKLP AISPSHVEPG TDLPPLYSIQ
RGGHSSGQYR RASSLSSNST STSGSSSFNS SLAPSNVASG TTTPRGSTPP RGVPTKRHTE
DEIVRGVKRL ELGPAEPLRS TTPELPDSGT TEQALERDQK PDISALSLSS SPTPPSNNPP
PSVSTANEEG KDMTIEEMRR RHAALIKSWL VAVNLQWRRK KMEEMQRQQR EEMEELEEGG
EAMNVDERER ERVEVVA
