ID   PACC_GIBFU              Reviewed;         618 AA.
AC   Q8J1U9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium
OS   fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=5127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=m567;
RA   Tudzynski B., Selle A.;
RT   "Cloning and functional analysis of the Gibberella fujikuroi PACC-encoding
RT   gene.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AJ514259; CAD55803.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8J1U9; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..618
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046834"
FT   ZN_FING         62..87
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         98..122
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         128..150
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           456..459
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           610..613
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        7..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..586
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   618 AA;  66994 MW;  23C854EF17127BD6 CRC64;
     MSPPAPEQKP QLQQQQQQQG SSSGDSSSGS ANDSKSVTPA PSATSNTSQS STAPSTSSDD
     NLICRWNACN QKFPAPEALY EHICERHVGR KSTNNLNLTC QWNSCRTTTV KRDHITSHIR
     VHVPLKPHKC DFCGKSFKRP QDLKKHVKTH ADDSVLVRPS QDPQGGLNYR PQPPKGMSHL
     DSSPRLYYDH TGQMRTNAAA FAHQAGHPSG GYYAPQPSTN YGLYFNQPPI NNARTEHLGY
     SAAAGGYDRK RTYDMVDDFF GSAKRRQIDP SSYAQIGRSL MPLHGNLSVP NGPMTATEQY
     MPQPAPAPVH AGPTPSQNPL AQQYYLPMPS ARTQKDLIHI DTILGQMQDT IYENANHATA
     GVHIHHAENG FNGYRNTPSP PTSHRSPTGM HVGADGYQPV SAASMASPLT AISSTGTPAV
     TPPSSSMSYT SGHSPSPSSS AMSPQSRHGS TASVMYPTLP TSLPAVSQGF GHSATTTLGP
     SFDGSERRRY SGGMLQRARA GPLPLPREDT SGASTPKASE SALSVGSPSS ESDVSDATRE
     REEQYDRWLE NMRVIETLRE YVRGRLERKE FVEDNESPRS SHSDAMDVDP KSPQAPPREL
     GTPREGSSLY PILRMPGA