ID   PACC_GIBMO              Reviewed;         613 AA.
AC   Q873X0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=PAC1;
OS   Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium
OS   verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=117187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600;
RX   PubMed=12957906; DOI=10.1128/aem.69.9.5222-5227.2003;
RA   Flaherty J.E., Pirttilae A.M., Bluhm B.H., Woloshuk C.P.;
RT   "PAC1, a pH-regulatory gene from Fusarium verticillioides.";
RL   Appl. Environ. Microbiol. 69:5222-5227(2003).
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including PAC1 itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds to DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AY216461; AAO64251.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q873X0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..613
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046835"
FT   ZN_FING         64..89
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         100..124
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         130..152
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           451..454
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           605..608
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        406..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  66373 MW;  A62E65148E5CD775 CRC64;
     MSPSAPEQKP QLQQQQQQQQ QGSSSGDSSS GSVNDSKSVT PAPSATSSTS QSSTAPSTSS
     DDNLICRWNA CNQKFPAPEA LYEHICERHV GRKSTNNLNL TCQWNSCRTT TVKRDHITSH
     IRVHVPLKPH KCEFCGKSFK RPQDLKKHVK THADDSVLVR PSQDPQGGLN YRPQPPKGPS
     SYYDHTGQMR TNAAAFAHQA GHPSGGYYAP QPSTNYGLYF NQPPINNART EHLGYSAAAG
     GYDRKRTYDM VDDFFGSAKR RQIDPSSYAQ IGRSLMPLHG NLSVPNGPMT ATEQYMPQPA
     PAPVHAGPTP SQNPLAQQYY LPMPSARTQK DLIHIDTILG QMQDTIYENA NHATAGVHIH
     HAENGFNGYR NTPSPPTSHR SPTGMHVGAD GYQPVSAASM ASPMTAISST GTPAVTPPSS
     SMSYTSGHSP SPSSSAMSPQ SRHGSTASVM YPTLPTSLPA VSQGFGHSAT TTLGPSFDGS
     ERRRYSGGML QRARAGPLPL PHEDTSGAST PKASESALSV GSPSSESDVS DATREREEQY
     DRWLENMRVI ETLREYVRGR LERKEFVEDN ESPQSSHSDA MDVDPKSPQA PPRELGTPRE
     GSSLYPILRM PGA