ID   PACC_PARBR              Reviewed;         706 AA.
AC   Q8J257;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Paracoccidioides brasiliensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=121759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Aguiar S.M., Mello-de-Sousa T.M., Neves E.O., Pocas-Fonseca M.J.;
RT   "Structural and expression analysis of the transcriptional factor encoding
RT   gene pacc of Paracoccidioides brasiliensis.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AF536981; AAN06812.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q8J257; -.
DR   VEuPathDB; FungiDB:PABG_11557; -.
DR   VEuPathDB; FungiDB:PADG_00964; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..706
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046839"
FT   ZN_FING         92..117
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         128..152
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         158..180
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          573..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..675
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  75057 MW;  AF638EFD1BFBFF5F CRC64;
     MSSRENPDTS APMAQQQPQQ QQQQQQPQPQ QQQQQQQQQQ QAQQTTQQQQ SPQQPSQQSP
     LPAAAAAASV IAPVPLPQNG SNGAALGVTE NLVCQWQGCQ ERLPTAEALY EHVCERHVGR
     KSTNNLNLTC GWANCRTTTV KRDHITSHIR VHVPLKPHKC DFCGKAFKRP QDLKKHVKTH
     ADDSVLVRSP EPGPGTRPPN GMFGVGVGAD GKCSLGHVHG QGYPHGAPQY YQTPHQQHPS
     NPSYGNVYYA IGSDSHQASY ESKKRGYDAL NEFFGDLKRR QFDPTSYAVV GQRLLNLHGL
     PLPLVNGAAV AVPEYQTQPM PAMVSVGHGG GHSGGGGYQP ASPMQSYHLP PMGNLRTKAD
     LMNIDQFLEQ MQSTVYESDD HVAAAGVAQP GAHYVQHGGM SYRTSHSSNN ANANANASHT
     ATSSPPSAAT NIPSTHATAT TTTTSAPMIP TSSAARLLPT HAPRHALTPP SSAQSYTSGR
     SPVSVSSTHH HIPPSHHYTH THNHNHNHPN SSAGMYPTLP ATSAQDGSST NTYHGVSGAA
     APSTLSSVFD SEGGRRYAGG CCRGLDRGLW RRHHRRRQGS PSMSFAEVGG NDTKTASPSM
     SFSASVIDPA LQAGSEKQSG SSGSGGEAGA GAGAGAGAGE ERNGSSSSPT ADVEEVSRAL
     SSANATTTMA TKTAPPEVPS HTVEQWVANV RLLEKLRLYI YERLSR