ID   PACC_SCLSC              Reviewed;         625 AA.
AC   Q9P413;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pac1;
OS   Sclerotinia sclerotiorum (White mold) (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=5180;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX   PubMed=11133430; DOI=10.1128/aem.67.1.75-81.2001;
RA   Rollins J.A., Dickman M.B.;
RT   "pH signaling in Sclerotinia sclerotiorum: identification of a pacC/RIM1
RT   homolog.";
RL   Appl. Environ. Microbiol. 67:75-81(2001).
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pac1 itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- INDUCTION: By alkaline conditions. {ECO:0000269|PubMed:11133430}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY005467; AAF93178.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9P413; -.
DR   VEuPathDB; FungiDB:sscle_06g049830; -.
DR   OMA; QWGNCRT; -.
DR   PHI-base; PHI:314; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..625
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046843"
FT   ZN_FING         45..70
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         81..105
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         111..133
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           444..447
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           615..618
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        457..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        601..618
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  67866 MW;  6453CB98B7650F45 CRC64;
     MSSQDQQQQQ QPAQTQTSTS SSSNNENATT ATSSIQQNVV ADDSLLCQWE KCSERCPTPE
     ALFDHICEKH VGRKSTNNLN LTCGWNSCRT TTVKRDHITS HIRVHVPLKP HKCEFCGKAF
     KRPQDLKKHV KTHADDSVLL RTPEQSGGSN GGYRQPGGKV IANLQHLAAN PMGYYDHNAS
     MHPGSAGVYG NSHHGGHSGY YAPAHSQQSS YGGGPGYYQM SHNPDLGQHA AWDEKKRNFD
     NLNDFFGAAK RRQIDAHSYQ QVNQRLMQLQ GIPIGTGGGI SDYIHSAPQL VPIDGHGGHG
     HGGPMPQHQY SLPLPNLRTK SDLNSIDQFL EQMQSTVYES SNAAAAAGIH QPGAHYTHQA
     LNFRQSHSPP QTHIHNIGSM APHVSTSYAS APMTATHSSH SVSSGTPALT PPSSSVSYTS
     GNSPMSSSGM SPISRHSSTS NAAYPNLPAV TLGYSPHHSA TAPTSTLGTN FDSDPRRRYS
     GGVLQRSAGG LNSSQYRESM ETSTVGSPTP SPKETTPRPE SIVKTEVTNN IDPALSDAGS
     PSVRSVDTLE SARDRAEEAW IENIRVIEAL RRYVSDRLQN GEYVKDEEDE DVSMADTDMQ
     DTQVKTEEKP VESLYPVLKT DDDDE