ID   PACC_TRIRU              Reviewed;         758 AA.
AC   Q9C1A4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=pH-response transcription factor pacC/RIM101;
GN   Name=pacC;
OS   Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=5551;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ferreira-Nozawa M.S., Nozawa S.R., Rossi A., Fachin A.L.,
RA   Maccheroni W. Jr., Martinez-Rossi N.M.;
RT   "Cloning of a zinc (Zn)-finger transcription factor pacC gene from the
RT   dermatophyte Trichophyton rubrum.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that mediates regulation of both
CC       acid- and alkaline-expressed genes in response to ambient pH. At
CC       alkaline ambient pH, activates transcription of alkaline-expressed
CC       genes (including pacC itself) and represses transcription of acid-
CC       expressed genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Activated by C-terminal proteolytic cleavage by signaling protease
CC       (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
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DR   EMBL; AF363788; AAK35072.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q9C1A4; -.
DR   VEuPathDB; FungiDB:TERG_00838; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..758
FT                   /note="pH-response transcription factor pacC/RIM101"
FT                   /id="PRO_0000046844"
FT   ZN_FING         84..109
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         120..144
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         150..172
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          635..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           486..489
FT                   /note="YPX[LI] motif 1"
FT   MOTIF           736..739
FT                   /note="YPX[LI] motif 2"
FT   COMPBIAS        214..228
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..657
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..710
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  80946 MW;  69EF7A46FAA19F65 CRC64;
     MQSASSLQQQ QPQQQQQQQP QQQGQQQGQQ AQQQQGQQQQ PASQTVQSVP VQANLQHAAA
     AAAAVAPPGV QQVAPNSPSA PGSLECQWQG CQELCPTPEA LYEHVCERHV GRKSTNNLNL
     TCGWSNCRTT TVKRDHITSH IRVHVPLKPH KCDFCGKAFK RPQDLKKHVK THADDSVLMR
     SPEPGAGQRQ QPPAGMFGVG LGPDGKRSLG PVPQAYGHPP PQYYQPQHPQ QQPNPSYGNV
     YYAVGHDAAH QASYESKKRG YDALNEFFGD LKRRQFDPTS YAAVGQRLLN LHGLPLPLTH
     AGAVPEYQPM PAMVGVGGGH GGYQSAGPIP TQSYHLPPMG NLRTKADLMN IDQFLEQMQS
     TVYESDENVA AAGVAQPGAH YVQGPLSYRT TNSPPTHHQS HHQHPHATAT AAATTTAATT
     ASMMSTSAAA TPASSISAAS RSPHASTPAL TPPSSAQSYT SGRSPISLAS SHGMSPSHHP
     STAGMYPTLP ATTGQDSLSS SGYPTTVSSA APPSTLSSVF DDDRRRYTGG MLQRSRPDID
     LSTPSIKRDD ADATAGKDEP KLSSSVIDPA LSRASVDMDE DAAPHRSPSS TPTPTATTAA
     AGPDDRQPAG EQQWVENVRL LQRLRDYVLE RLNNGDYVDE DKQDDSDKEE DAKSDKASPE
     SASASDAATG AGEYPSIKMH GMEAIAAAAV AHEEGRDDQM PRDDEDQENP STPTARSTTT
     MLDAEEEAKQ AGENLYPVLK MAVDDDGADT DGDEKMGQ