ID   PACE_ACIAD              Reviewed;         141 AA.
AC   Q6FAW0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   23-FEB-2022, entry version 80.
DE   RecName: Full=Short-chain diamines transporter {ECO:0000250|UniProtKB:P0DUT9};
DE   AltName: Full=Acinetobacter chlorhexidine efflux protein I {ECO:0000303|PubMed:24277845};
GN   Name=aceI {ECO:0000303|PubMed:24277845};
GN   OrderedLocusNames=ACIAD1978 {ECO:0000312|EMBL:CAG68803.1};
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=24277845; DOI=10.1073/pnas.1317052110;
RA   Hassan K.A., Jackson S.M., Penesyan A., Patching S.G., Tetu S.G.,
RA   Eijkelkamp B.A., Brown M.H., Henderson P.J., Paulsen I.T.;
RT   "Transcriptomic and biochemical analyses identify a family of chlorhexidine
RT   efflux proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20254-20259(2013).
CC   -!- FUNCTION: Mediates the efflux of short-chain diamines when energized by
CC       an electrochemical gradient (By similarity). Involved in resistance to
CC       the synthetic biocide chlorhexidine, a widely used antiseptic and
CC       disinfectant in both hospital and community settings (PubMed:24277845).
CC       Interacts directly with chlorhexidine and mediates its efflux via an
CC       energy-dependent mechanism (By similarity).
CC       {ECO:0000250|UniProtKB:P0DUT9, ECO:0000269|PubMed:24277845}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0DUT9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- INDUCTION: Induced by chlorhexidine. {ECO:0000269|PubMed:24277845}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant shows increased chlorhexidine
CC       susceptibility. {ECO:0000269|PubMed:24277845}.
CC   -!- SIMILARITY: Belongs to the proteobacterial antimicrobial compound
CC       efflux (PACE) (TC 2.A.117) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG68803.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR543861; CAG68803.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_004927292.1; NC_005966.1.
DR   STRING; 62977.ACIAD1978; -.
DR   EnsemblBacteria; CAG68803; CAG68803; ACIAD1978.
DR   GeneID; 45234340; -.
DR   KEGG; aci:ACIAD1978; -.
DR   eggNOG; COG4125; Bacteria.
DR   HOGENOM; CLU_120004_1_1_6; -.
DR   OMA; MWVLQLD; -.
DR   Proteomes; UP000000430; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007896; BTP_bacteria.
DR   Pfam; PF05232; BTP; 2.
PE   2: Evidence at transcript level;
KW   Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Stress response; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..141
FT                   /note="Short-chain diamines transporter"
FT                   /id="PRO_0000453612"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   141 AA;  16410 MW;  2DF49078DD372F7A CRC64;
     MLISKRRMIH ALSYEVILLV IIAIALSFIF DVPLEVTGTL GIVMAVTSVF WNMIFNHFFE
     KFERKHQLER TVKIRILHAI GFEGGLMLVT IPMVAYAMNM SLWQAIVLDF GLTMCILVYT
     FIFQWCYDTI EKRLGYTPRH S