PACE_VIBPA
ID PACE_VIBPA Reviewed; 140 AA.
AC Q87QJ4;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 23-FEB-2022, entry version 66.
DE RecName: Full=Short-chain diamines transporter {ECO:0000250|UniProtKB:P0DUT9};
DE AltName: Full=Antimicrobial compound efflux protein VP1155 {ECO:0000305};
GN OrderedLocusNames=VP1155 {ECO:0000312|EMBL:BAC59418.1};
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633;
RX PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
RN [2]
RP FUNCTION, AND NOMENCLATURE.
RX PubMed=25670776; DOI=10.1128/mbio.01982-14;
RA Hassan K.A., Liu Q., Henderson P.J., Paulsen I.T.;
RT "Homologs of the Acinetobacter baumannii AceI transporter represent a new
RT family of bacterial multidrug efflux systems.";
RL MBio 6:0-0(2015).
CC -!- FUNCTION: Mediates the efflux of short-chain diamines when energized by
CC an electrochemical gradient (By similarity). Confers resistance to
CC chlorhexidine, benzalkonium, proflavine and acriflavine. Mediates
CC efflux of both proflavine and acriflavine via an energy-dependent
CC mechanism (PubMed:25670776). {ECO:0000250|UniProtKB:P0DUT9,
CC ECO:0000269|PubMed:25670776}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0DUT9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the proteobacterial antimicrobial compound
CC efflux (PACE) (TC 2.A.117) family. {ECO:0000305|PubMed:25670776}.
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DR EMBL; BA000031; BAC59418.1; -; Genomic_DNA.
DR RefSeq; NP_797534.1; NC_004603.1.
DR RefSeq; WP_005462438.1; NC_004603.1.
DR STRING; 223926.28806143; -.
DR TCDB; 2.A.117.1.13; the chlorhexadine exporter (chx) family.
DR EnsemblBacteria; BAC59418; BAC59418; BAC59418.
DR GeneID; 1188660; -.
DR KEGG; vpa:VP1155; -.
DR PATRIC; fig|223926.6.peg.1096; -.
DR eggNOG; COG4125; Bacteria.
DR HOGENOM; CLU_120004_1_0_6; -.
DR OMA; CFNLAYD; -.
DR Proteomes; UP000002493; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR007896; BTP_bacteria.
DR Pfam; PF05232; BTP; 2.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..140
FT /note="Short-chain diamines transporter"
FT /id="PRO_0000453613"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 140 AA; 15913 MW; C9F25C9654026FFD CRC64;
MTRNERIFHA VLFELMALAI IVPAAALITG KGSSDLALVG IGLSLYTVVW NYIYNLYFDK
WFGSNRADRS LAMRLGHTVG FEGGLIFISI PVIAWFLEIT FLRALMLEAG FLVFFLFYAT
GFNWLYDKVQ PFGKMRKLLV
