PACRG_BOVIN
ID PACRG_BOVIN Reviewed; 257 AA.
AC A5PK71;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Parkin coregulated gene protein;
GN Name=PACRG;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000312|EMBL:AAI42384.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating (PubMed:34715025). Suppresses cell death induced
CC by accumulation of unfolded Pael receptor (Pael-R, a substrate of
CC Parkin). Facilitates the formation of inclusions consisting of Pael-R,
CC molecular chaperones, protein degradation molecules and itself when
CC proteasome is inhibited. May play an important role in the formation of
CC Lewy bodies and protection of dopaminergic neurons against Parkinson
CC disease (By similarity). {ECO:0000250|UniProtKB:Q96M98,
CC ECO:0000269|PubMed:34715025}.
CC -!- SUBUNIT: Forms a large molecular chaperone complex containing heat
CC shock proteins 70 and 90 and chaperonin components. Interacts with
CC STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A,
CC CCT7, CCT8. Interacts with MEIG1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
CC -!- MISCELLANEOUS: Linked to PRKN in a head-to-head arrangement on opposite
CC DNA strands and share a common 5'-flanking promoter region.
CC {ECO:0000250|UniProtKB:Q96M98}.
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DR EMBL; BC142383; AAI42384.1; -; mRNA.
DR PDB; 7RRO; EM; 3.40 A; YB/YC/YD/YE/YF/YG=1-257.
DR PDBsum; 7RRO; -.
DR SMR; A5PK71; -.
DR STRING; 9913.ENSBTAP00000014748; -.
DR Ensembl; ENSBTAT00000014748.5; ENSBTAP00000014748.4; ENSBTAG00000011106.5.
DR VEuPathDB; HostDB:ENSBTAG00000011106; -.
DR VGNC; VGNC:55070; PACRG.
DR eggNOG; KOG3961; Eukaryota.
DR GeneTree; ENSGT00940000157330; -.
DR HOGENOM; CLU_073223_1_0_1; -.
DR OMA; INGPIHE; -.
DR TreeFam; TF321123; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000011106; Expressed in spermatid and 64 other tissues.
DR ExpressionAtlas; A5PK71; baseline.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0002177; C:manchette; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR InterPro; IPR019399; Parkin_co-regulated_protein.
DR PANTHER; PTHR21207; PTHR21207; 1.
DR Pfam; PF10274; ParcG; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..257
FT /note="Parkin coregulated gene protein"
FT /id="PRO_0000456157"
SQ SEQUENCE 257 AA; 29284 MW; 53838564402990A1 CRC64;
MVAEKETLSL NKCPAKLPTR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPSAG
AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI EKLDYHHYLP LFFDGLCEMT
FPYEFFARQG IHDMLEHGGN KILPVIPQLI IPIKNALNLR NRQVICVTLK VLQHLVVSAE
MVGEALVPYY RQILPILNIF KNKNVNSGDG IDYSQQKREN IGDLIQETLE AFERYGGEDA
FINIKYMVPT YESCLLN
