PACRG_MOUSE
ID PACRG_MOUSE Reviewed; 241 AA.
AC Q9DAK2; Q7TPF9; Q8CG20;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Parkin coregulated gene protein homolog;
DE AltName: Full=Hypertension-related protein 1-like protein;
DE AltName: Full=PARK2 coregulated gene protein;
GN Name=Pacrg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 37-82 AND 140-241.
RC STRAIN=C57BL/6J;
RA Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D.,
RA Nagaraja R.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH MEIG1.
RX PubMed=19805151; DOI=10.1073/pnas.0906414106;
RA Zhang Z., Shen X., Gude D.R., Wilkinson B.M., Justice M.J.,
RA Flickinger C.J., Herr J.C., Eddy E.M., Strauss J.F. III;
RT "MEIG1 is essential for spermiogenesis in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:17055-17060(2009).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating (By similarity). Suppresses cell death induced by
CC accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin).
CC Facilitates the formation of inclusions consisting of Pael-R, molecular
CC chaperones, protein degradation molecules and itself when proteasome is
CC inhibited. May play an important role in the formation of Lewy bodies
CC and protection of dopaminergic neurons against Parkinson disease (By
CC similarity). {ECO:0000250|UniProtKB:A5PK71,
CC ECO:0000250|UniProtKB:Q96M98}.
CC -!- SUBUNIT: Forms a large molecular chaperone complex containing heat
CC shock proteins 70 and 90 and chaperonin components. Interacts with
CC STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A,
CC CCT7 and CCT8 (By similarity). Interacts with MEIG1. {ECO:0000250,
CC ECO:0000269|PubMed:19805151}.
CC -!- INTERACTION:
CC Q9DAK2; Q61845: Meig1; NbExp=3; IntAct=EBI-8572392, EBI-15805257;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A5PK71}.
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DR EMBL; AK005771; BAB24230.1; -; mRNA.
DR EMBL; AC109609; AAP94052.1; -; Genomic_DNA.
DR EMBL; AF549257; AAO16245.1; -; Genomic_DNA.
DR CCDS; CCDS28388.1; -.
DR RefSeq; NP_081308.1; NM_027032.2.
DR AlphaFoldDB; Q9DAK2; -.
DR SMR; Q9DAK2; -.
DR DIP; DIP-48983N; -.
DR IntAct; Q9DAK2; 2.
DR MINT; Q9DAK2; -.
DR STRING; 10090.ENSMUSP00000044376; -.
DR PhosphoSitePlus; Q9DAK2; -.
DR MaxQB; Q9DAK2; -.
DR PaxDb; Q9DAK2; -.
DR PRIDE; Q9DAK2; -.
DR ProteomicsDB; 294241; -.
DR Antibodypedia; 20047; 158 antibodies from 25 providers.
DR DNASU; 69310; -.
DR Ensembl; ENSMUST00000041463; ENSMUSP00000044376; ENSMUSG00000037196.
DR GeneID; 69310; -.
DR KEGG; mmu:69310; -.
DR UCSC; uc008akg.1; mouse.
DR CTD; 135138; -.
DR MGI; MGI:1916560; Pacrg.
DR VEuPathDB; HostDB:ENSMUSG00000037196; -.
DR eggNOG; KOG3961; Eukaryota.
DR GeneTree; ENSGT00940000157330; -.
DR HOGENOM; CLU_073223_1_0_1; -.
DR InParanoid; Q9DAK2; -.
DR OMA; INGPIHE; -.
DR OrthoDB; 1095804at2759; -.
DR PhylomeDB; Q9DAK2; -.
DR TreeFam; TF321123; -.
DR BioGRID-ORCS; 69310; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Pacrg; mouse.
DR PRO; PR:Q9DAK2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9DAK2; protein.
DR Bgee; ENSMUSG00000037196; Expressed in seminiferous tubule of testis and 136 other tissues.
DR ExpressionAtlas; Q9DAK2; baseline and differential.
DR Genevisible; Q9DAK2; MM.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0044297; C:cell body; IDA:MGI.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
DR GO; GO:0002177; C:manchette; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
DR GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR GO; GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
DR GO; GO:0003779; F:actin binding; ISO:MGI.
DR GO; GO:0043014; F:alpha-tubulin binding; ISO:MGI.
DR GO; GO:0048487; F:beta-tubulin binding; ISO:MGI.
DR GO; GO:0051087; F:chaperone binding; ISO:MGI.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0031072; F:heat shock protein binding; ISO:MGI.
DR GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI.
DR GO; GO:0051879; F:Hsp90 protein binding; ISO:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
DR GO; GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
DR GO; GO:0060548; P:negative regulation of cell death; IMP:ParkinsonsUK-UCL.
DR GO; GO:0008104; P:protein localization; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IGI:MGI.
DR InterPro; IPR019399; Parkin_co-regulated_protein.
DR PANTHER; PTHR21207; PTHR21207; 1.
DR Pfam; PF10274; ParcG; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..241
FT /note="Parkin coregulated gene protein homolog"
FT /id="PRO_0000058170"
SQ SEQUENCE 241 AA; 27726 MW; C871D590AA773AC1 CRC64;
MPKRTKLLPQ QTFQVHQPRS LVSEGFTVKA MMKNSVVRGP PVAGAFKERP AKPTTFRKCY
ERGDFPIALE HDSKGNKIAW KVEIEKLDYH HYLPLFFDGL SEMTFPYEFF ARRGIHDMLE
HGGNKILPVI PQLIIPIKNA LNLRNRQIIC VTLKVLQHLV VSSEMVGEAL LPYYRQILPI
LNIFKNMNVN SGDGIDYSQQ KRENIGDLIQ ETLEAFERYG GEDAFINIKY MVPTYESCLL
N
