PACRL_HUMAN
ID PACRL_HUMAN Reviewed; 248 AA.
AC Q8N7B6; B2RDB9; B4DFF8; B4DMN7; Q8TBA8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=PACRG-like protein;
GN Name=PACRGL; Synonyms=C4orf28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q8N7B6; P15173: MYOG; NbExp=3; IntAct=EBI-3925298, EBI-3906629;
CC Q8N7B6; Q96D15: RCN3; NbExp=3; IntAct=EBI-3925298, EBI-746283;
CC Q8N7B6-2; Q15699: ALX1; NbExp=3; IntAct=EBI-10694433, EBI-750671;
CC Q8N7B6-2; Q5H9J7: BEX5; NbExp=3; IntAct=EBI-10694433, EBI-10243741;
CC Q8N7B6-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10694433, EBI-618309;
CC Q8N7B6-2; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-10694433, EBI-1054873;
CC Q8N7B6-2; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10694433, EBI-1055254;
CC Q8N7B6-2; P13349: MYF5; NbExp=3; IntAct=EBI-10694433, EBI-17491620;
CC Q8N7B6-2; P15173: MYOG; NbExp=3; IntAct=EBI-10694433, EBI-3906629;
CC Q8N7B6-2; P19404: NDUFV2; NbExp=3; IntAct=EBI-10694433, EBI-713665;
CC Q8N7B6-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10694433, EBI-5235340;
CC Q8N7B6-2; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-10694433, EBI-745958;
CC Q8N7B6-2; Q6F5E7: TXNRD3NB; NbExp=3; IntAct=EBI-10694433, EBI-18122152;
CC Q8N7B6-2; P54577: YARS1; NbExp=3; IntAct=EBI-10694433, EBI-1048893;
CC Q8N7B6-2; Q96DT7-3: ZBTB10; NbExp=3; IntAct=EBI-10694433, EBI-12017160;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N7B6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7B6-2; Sequence=VSP_023206;
CC Name=3;
CC IsoId=Q8N7B6-3; Sequence=VSP_043351, VSP_023206;
CC Name=4;
CC IsoId=Q8N7B6-4; Sequence=VSP_045095, VSP_045096;
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DR EMBL; AK098692; BAC05381.1; -; mRNA.
DR EMBL; AK297556; BAG59949.1; -; mRNA.
DR EMBL; AK315482; BAG37866.1; -; mRNA.
DR EMBL; AK294077; BAG57419.1; -; mRNA.
DR EMBL; AC097505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104065; AAY40910.1; -; Genomic_DNA.
DR EMBL; BC023002; AAH23002.1; -; mRNA.
DR CCDS; CCDS3427.1; -. [Q8N7B6-2]
DR CCDS; CCDS47034.1; -. [Q8N7B6-3]
DR CCDS; CCDS58895.1; -. [Q8N7B6-1]
DR CCDS; CCDS58896.1; -. [Q8N7B6-4]
DR RefSeq; NP_001124199.1; NM_001130727.2. [Q8N7B6-3]
DR RefSeq; NP_001245274.1; NM_001258345.2. [Q8N7B6-1]
DR RefSeq; NP_001245275.1; NM_001258346.2. [Q8N7B6-4]
DR RefSeq; NP_001317674.1; NM_001330745.1.
DR RefSeq; NP_001317675.1; NM_001330746.1.
DR RefSeq; NP_001317676.1; NM_001330747.1.
DR RefSeq; NP_001317677.1; NM_001330748.1.
DR RefSeq; NP_659485.1; NM_145048.4. [Q8N7B6-2]
DR RefSeq; XP_011512107.1; XM_011513805.2. [Q8N7B6-2]
DR RefSeq; XP_016863237.1; XM_017007748.1. [Q8N7B6-1]
DR RefSeq; XP_016863238.1; XM_017007749.1. [Q8N7B6-1]
DR RefSeq; XP_016863240.1; XM_017007751.1. [Q8N7B6-2]
DR RefSeq; XP_016863241.1; XM_017007752.1. [Q8N7B6-2]
DR RefSeq; XP_016863242.1; XM_017007753.1. [Q8N7B6-2]
DR RefSeq; XP_016863247.1; XM_017007758.1. [Q8N7B6-3]
DR RefSeq; XP_016863248.1; XM_017007759.1. [Q8N7B6-3]
DR AlphaFoldDB; Q8N7B6; -.
DR SMR; Q8N7B6; -.
DR BioGRID; 126346; 15.
DR IntAct; Q8N7B6; 19.
DR STRING; 9606.ENSP00000423881; -.
DR iPTMnet; Q8N7B6; -.
DR PhosphoSitePlus; Q8N7B6; -.
DR BioMuta; PACRGL; -.
DR DMDM; 126215685; -.
DR MassIVE; Q8N7B6; -.
DR MaxQB; Q8N7B6; -.
DR PeptideAtlas; Q8N7B6; -.
DR PRIDE; Q8N7B6; -.
DR ProteomicsDB; 4032; -.
DR ProteomicsDB; 72280; -. [Q8N7B6-1]
DR ProteomicsDB; 72281; -. [Q8N7B6-2]
DR ProteomicsDB; 72282; -. [Q8N7B6-3]
DR Antibodypedia; 43692; 58 antibodies from 12 providers.
DR DNASU; 133015; -.
DR Ensembl; ENST00000295290.12; ENSP00000295290.8; ENSG00000163138.19. [Q8N7B6-2]
DR Ensembl; ENST00000360916.9; ENSP00000354171.4; ENSG00000163138.19. [Q8N7B6-2]
DR Ensembl; ENST00000444671.6; ENSP00000415832.2; ENSG00000163138.19. [Q8N7B6-3]
DR Ensembl; ENST00000467997.6; ENSP00000423477.1; ENSG00000163138.19. [Q8N7B6-2]
DR Ensembl; ENST00000471979.6; ENSP00000423914.2; ENSG00000163138.19. [Q8N7B6-1]
DR Ensembl; ENST00000502374.5; ENSP00000425461.1; ENSG00000163138.19. [Q8N7B6-4]
DR Ensembl; ENST00000503585.6; ENSP00000423881.1; ENSG00000163138.19. [Q8N7B6-1]
DR Ensembl; ENST00000506702.5; ENSP00000423536.1; ENSG00000163138.19. [Q8N7B6-2]
DR Ensembl; ENST00000507634.5; ENSP00000425938.1; ENSG00000163138.19. [Q8N7B6-2]
DR GeneID; 133015; -.
DR KEGG; hsa:133015; -.
DR MANE-Select; ENST00000503585.6; ENSP00000423881.1; NM_001258345.3; NP_001245274.1.
DR UCSC; uc003gpu.4; human. [Q8N7B6-1]
DR CTD; 133015; -.
DR DisGeNET; 133015; -.
DR GeneCards; PACRGL; -.
DR HGNC; HGNC:28442; PACRGL.
DR HPA; ENSG00000163138; Low tissue specificity.
DR neXtProt; NX_Q8N7B6; -.
DR OpenTargets; ENSG00000163138; -.
DR PharmGKB; PA164724318; -.
DR VEuPathDB; HostDB:ENSG00000163138; -.
DR eggNOG; KOG3961; Eukaryota.
DR GeneTree; ENSGT00940000159756; -.
DR HOGENOM; CLU_070957_1_0_1; -.
DR InParanoid; Q8N7B6; -.
DR OMA; HKLQWEC; -.
DR OrthoDB; 1327344at2759; -.
DR PhylomeDB; Q8N7B6; -.
DR TreeFam; TF321123; -.
DR PathwayCommons; Q8N7B6; -.
DR SignaLink; Q8N7B6; -.
DR BioGRID-ORCS; 133015; 7 hits in 1073 CRISPR screens.
DR ChiTaRS; PACRGL; human.
DR GenomeRNAi; 133015; -.
DR Pharos; Q8N7B6; Tdark.
DR PRO; PR:Q8N7B6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N7B6; protein.
DR Bgee; ENSG00000163138; Expressed in sperm and 151 other tissues.
DR ExpressionAtlas; Q8N7B6; baseline and differential.
DR Genevisible; Q8N7B6; HS.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019399; Parkin_co-regulated_protein.
DR PANTHER; PTHR21207; PTHR21207; 1.
DR Pfam; PF10274; ParcG; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..248
FT /note="PACRG-like protein"
FT /id="PRO_0000278243"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D3X5"
FT VAR_SEQ 70..167
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043351"
FT VAR_SEQ 70..122
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045095"
FT VAR_SEQ 203..229
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023206"
FT VAR_SEQ 204..248
FT /note="LSKRLMDKKFKEPITSALQKLEQHGGSGSLSIIKSKIPTYCSICC -> DPV
FT QLMRFPRPLLGLMICQKDPWNSGKLLLAVMVSYNTQKIKIKISKGEP (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045096"
FT CONFLICT 104
FT /note="W -> R (in Ref. 1; BAC05381)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 248 AA; 27152 MW; 01E1EB06F10E85F7 CRC64;
MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD
KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH RLQWECPPES LSFDPLLITL
AEGLRETKHP YTFVSKEGFR ELLLVKGAPE KAIPLLPRLI PVLKAALVHS DDEVFERGLN
ALVQLSVVVG PSLNDHLKHL LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI
PTYCSICC
