ID   PAD1_CAEBR              Reviewed;        2340 AA.
AC   Q5WNI9; A8X5I6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Protein pad-1;
DE   AltName: Full=Patterning defective protein 1;
GN   Name=pad-1; ORFNames=CBG07989;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Essential for cell patterning during gastrulation. May be
CC       involved in protein traffic between late Golgi and early endosomes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
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DR   EMBL; HE600996; CAP27897.1; -; Genomic_DNA.
DR   RefSeq; XP_002646111.1; XM_002646065.1.
DR   AlphaFoldDB; Q5WNI9; -.
DR   STRING; 6238.CBG07989; -.
DR   EnsemblMetazoa; CBG07989.1; CBG07989.1; WBGene00029864.
DR   GeneID; 8588172; -.
DR   KEGG; cbr:CBG_07989; -.
DR   CTD; 8588172; -.
DR   WormBase; CBG07989; CBP02002; WBGene00029864; Cbr-pad-1.
DR   eggNOG; KOG3613; Eukaryota.
DR   HOGENOM; CLU_001045_0_0_1; -.
DR   InParanoid; Q5WNI9; -.
DR   OMA; QFQRNST; -.
DR   OrthoDB; 29961at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040314; DOP1.
DR   InterPro; IPR007249; Dopey_N.
DR   PANTHER; PTHR14042; PTHR14042; 1.
DR   Pfam; PF04118; Dopey_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..2340
FT                   /note="Protein pad-1"
FT                   /id="PRO_0000297951"
FT   REGION          411..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1910..1959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..434
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1910..1938
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1939..1957
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2340 AA;  260057 MW;  5823CDF9443066C3 CRC64;
     MASASGGDVP AGREKDSKYR AFAKAVDQAL KTFETPNEWA DLISALGKLA KVFQSNAKYC
     AIPNRVTVAK RLSQCLHPAL PMGVHLKALE TYKIIFEILG PSKLPECLYL FAVGLFPLMD
     HCGIKVKSEL FAIFENYLVP LGANLRPALP GFLGGVLLAL EEGTEFYERS FILLDRVCEK
     VGPRAFYACL WQAILGSPPV RLPAMIYVNA KFDKLKSLDD QIHLVGDHVN HMVAALCAVA
     DDTGSPLVQR YLLDFLCAAF PLDSTNLTDE DFVQLLRRCL FVVLRRDMSL NRRLYTWLIN
     RSGETRGVSG LGGPDDGLEL SFFKEKVLGL VHGALEQYLA LDIIETPFAN PQQSIWGDRK
     EAEQVQFAEV RVCRLLLYLQ DRADIGRTIL ETVFSDFLKK SAEFHQGSNI KLIKKRPDSK
     PPRKPGDREG LHLDLNSLHS GVSGNSEDVT APEGEPSIQS RRVDELSKTF NMLLNSLEPG
     FLWNFLGTWY QRIVEEGSEG KKSIHDFSQV VSICLEMSNV ESDPAIRTQH LPRLLETILE
     GLSNKSLISE CDQQDLLKLY TVCQKLLEIS TAHPQSPIEV DEIAEDSLSL SQEVTAIEHE
     RSQTDACLTQ CVSALSTIFE IYTTRRDPSL IPLIDASTAL LNAFLEVPIY YLGFDVVDNP
     EDVPSEVQQW LKNMLKVIDG PGWLKEMRNG HCSDVSARAS LLELLCKIYV KSVSVLQQHE
     EAAHRPQDDF YDEMTHVLLK PLLGRRDIQF IEQGKVFGTC GEAVWLGIAS RKFCCEQQRL
     ARLLVELHSR RPQEASSDVE SIVVQALTST DDLVCTKAAR TFHRVWVLTR NLEEAGGIYR
     KPFNRAVMIL LGVLADESVS KTRTELKAAA SAWFQDCSKH QDLPKIVQML STMLMNPVTA
     RISIQYIRQD SKLTNEDCSA IPSDVAAVTL MTIDGKQRLY HVTGSGADSD ASYLTEVRNR
     LLRASAGEET SEALQAHIIP STEVLPAFDD DTDSLDTLSM GNESPEDVVK DILAILVDEV
     CQEYEERERL HDLLNLSNLE ASGARFNLNE HEEQEESPED RPAPIAAVQR VKKGHRRQDS
     LQESIFNMTE KDLCAFDTSE IFRPSTESLR GTATTSSTRE TILPTGTVVG TVSSASSTGG
     STSGSSLFEE MHTHMLLYGE SGKVVDLARA ETAFRILTAL LAPRGATGNR MLLNCLVSSG
     TTTSSGTSSE GGSAEQSLVE LMQRHVRAIL GQHFWSAPAS DEEKHKHFTL LELLITISLH
     FLRSYFLNSP ISPVTEADLA SLWKCKISAL EFLCELFREL SAMLNEHESK QFVQFVQTIL
     NRSKLQKCLL HLLLTAVDHN PMENGKLGGP LSVSISKFNE GLVGESRRLL PLLAAYHRSL
     LTFTSHAIRL ECDIKRGFST FSDAQSTHRY SIIQSVINQS FNNRTSSRDG HASTVELRAF
     LLILLNALKK QPHRHEMWLQ FVVQILPWVE RSLATIVCRV VEQLCKNMEN AMSVAYENPP
     TSDVVVDSPG ETRDEPDSYP ANYLAMTLES LTTLVHFCVI DSAPTTTTTS GGVMTSSGAA
     QINDGTTPSS TSMVGHAMSV IPGSKVATEL FSQLGKVFSM SGDSGGVLSS KMESSRQHGN
     GWRQAQSDML TSLPHSLATV CNVWTVVRRA QNPLVPIGTN NQLRRLVLHL LSPIAQHHKH
     AFLTSLALVW LTRSTAKPTV TLRKQDPDRA TFEYSSAQLD ITNLLLSLQV IPFEDLISSV
     NSTLREASFK ANKVGITTID KTNFPTEEPL LELVHSCVSA VLQTQLRLCW SSLLSLFSEA
     PLSALSARAV FLLFVILSDF VKCVGGAYIV EDKAMYRNVQ EVCSRLAEAV NAIVGWQLET
     TTWLKRTLVV KQDHGTSSIN SNSIRSVEQS PIIEMQSSIS NLSSEASQST RNSTLSLINK
     PGGSITSGST STTTEKAEKK SSSNLRASIK DTNNNRRDPA HSTQALFLLA ERLTDLLDSV
     SKSDEKDKVL PTLQAVWANV VPYLKAKNAR NARFFLASSQ LLASMSSYSY MRPVWKKTTL
     DLLLDSGFFK MDHAALKQWL VVTDHLMTHD RTSFKDLLKS ISYSPNASFS IMTSKEQEYE
     ARAQALKRLT FVVFGSQLDQ YNGQMNDIQE RLSDNLRVSQ SPVIRSSFFL CVRVLLLRLR
     PHSLIGVWPI MVTELVHALS QLEQQLQNNG EQEGSSTSDQ WMQLYVAACK LLETLCTLPA
     GYLSHFQMFH WAFVSSVSAD KTEIFKPFAE RINDLLAKKY GEFDAMSNHT ASLAAVKILT
     SFEELRPFFY TLANLNKSVP ESNNTPLRDA HALSGSLTYK NAVARLESAL YVDFSEHLQF