PAD1_CAEEL
ID PAD1_CAEEL Reviewed; 2417 AA.
AC Q9XW10; Q9U5Z2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein pad-1;
DE AltName: Full=Patterning defective protein 1;
GN Name=pad-1; ORFNames=Y18D10A.13;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=10950924; DOI=10.1006/geno.2000.6250;
RA Guipponi M., Brunschwig K., Chamoun Z., Scott H.S., Shibuya K., Kudoh J.,
RA Delezoide A.-L., El Samadi S., Chettouh Z., Rossier C., Shimizu N.,
RA Mueller F., Delabar J.-M., Antonarakis S.E.;
RT "C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans
RT ortholog (pad-1) required for embryonic patterning.";
RL Genomics 68:30-40(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC early endosomes (By similarity). Essential for cell patterning during
CC gastrulation. {ECO:0000250, ECO:0000269|PubMed:10950924}.
CC -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
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DR EMBL; AJ250261; CAB59919.1; -; mRNA.
DR EMBL; AL034393; CAA22324.2; -; Genomic_DNA.
DR PIR; T26533; T26533.
DR RefSeq; NP_493252.3; NM_060851.4.
DR AlphaFoldDB; Q9XW10; -.
DR BioGRID; 38553; 3.
DR STRING; 6239.Y18D10A.13; -.
DR EPD; Q9XW10; -.
DR PaxDb; Q9XW10; -.
DR PeptideAtlas; Q9XW10; -.
DR EnsemblMetazoa; Y18D10A.13.1; Y18D10A.13.1; WBGene00003905.
DR GeneID; 173156; -.
DR KEGG; cel:CELE_Y18D10A.13; -.
DR UCSC; Y18D10A.13; c. elegans.
DR CTD; 173156; -.
DR WormBase; Y18D10A.13; CE27468; WBGene00003905; pad-1.
DR eggNOG; KOG3613; Eukaryota.
DR GeneTree; ENSGT00390000016421; -.
DR HOGENOM; CLU_001045_0_0_1; -.
DR InParanoid; Q9XW10; -.
DR OMA; WIDAVIQ; -.
DR OrthoDB; 29961at2759; -.
DR PhylomeDB; Q9XW10; -.
DR PRO; PR:Q9XW10; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003905; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040314; DOP1.
DR InterPro; IPR007249; Dopey_N.
DR PANTHER; PTHR14042; PTHR14042; 1.
DR Pfam; PF04118; Dopey_N; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; Protein transport; Reference proteome; Transport.
FT CHAIN 1..2417
FT /note="Protein pad-1"
FT /id="PRO_0000297952"
FT REGION 409..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1957..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1957..2004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2005..2030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 501..504
FT /note="FLWT -> SWGK (in Ref. 1; CAB59919)"
FT /evidence="ECO:0000305"
FT CONFLICT 508..510
FT /note="DWY -> NGN (in Ref. 1; CAB59919)"
FT /evidence="ECO:0000305"
FT CONFLICT 738
FT /note="V -> G (in Ref. 1; CAB59919)"
FT /evidence="ECO:0000305"
FT CONFLICT 2100
FT /note="S -> P (in Ref. 1; CAB59919)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2417 AA; 267153 MW; DAC7D4F9A5249E06 CRC64;
MASASGGDVP AGREKDSKYR AYAKAIDQAL KTFETPNEWA DLISALGKLA KVFQSNAKFC
AIPNRVTVAK RLSQCLHPAL PMGVHLKALE TYRQIFEILG PNKLPECLYL FAVGLFPLMD
HCGIKVKSEL FTIFENYLVP LGANLRPALP GFLGGVLLAL EEGTEFYERS FILLDRVCEK
VGPRAFYACL WQAILGSPPV RLPAMIYVNA KFDKLKSLDD QIHLVGDHVN HMVAALCAVA
DDTGSPLVQR YLLDFLVAAF PLDSTNLTNE DFVQLLRRCL FVVLRRDMSL NRRLYTWLIN
RSGETKGVSG LSLGGPDDGI ELTFFKERVL GLVHGALGEY LALDTIETPF ANHQNSMWGD
RKEAEQVQFA EVRVCRLLLY LQDRADIGRT ILETVFADFL KKSAEFHSSS NSSSLKKSPR
KIQQSLKNPR KPGDREGLYL DLNSVCSTSN KDDDVTSVTS SAAANASSAP PPDEEDLVQA
RRIDELSKTF NMLLNSLEPG FLWTFLGDWY RRIVENNEFE RQIHDFSQVV SVCLEMCNVE
SDPTIRTQHL PRLLETVLEG VSNKNLLSSC DQSDLLQLYT VCQKLLEIST AHPPSPIEVD
EIAEDSLSMS QEVTAIEHER SQTDACLSQC LSALSAIFEI YTTRREASLI PLIDASTTLL
NAFLEVPIYY LGFGIVDNPG DYCRESSEEV QPWLKNMLKV IDGPGWLREM RAGLCADVSA
RASLLELLCK IYVKSVQVLE QHEEAAHRPH DDFYDEMTHV LLKPLLAKRD CQFIEQGKVF
GTCGEAVWLG IGSRKFCTEQ QRLARLLVEL HSRRPLEASS DVESIVVQSL TSTDDLVCSE
AARTFHRIWV LARNLEDREQ QGIPYQKPFN RAVMILLGVL ADESVAKTRT ELKAAAAEWF
HDCSKHQDLP RIVQMLSTML MNPVTARISI QYIRQETKMT TDTCPVIPAD ISAVTLVTID
GKQRLYHVTG QPAIDSSSTE STWITEVRNR LLRTSTGEDS GDPSAAGAAG ILRSSSPDPD
VVPAFDDDTD SLDTLSMSDS IDETVIHVLR EIVDQVCEEF NEEDLERERI MTMFAMDNVE
PTGASFNLPH DSEADDEVAE RPAPICPDSL VQRVKKGHRR QDSLQESIFN MTDKDLSAFD
TSEIFRPSTE SVSRGTGAGA AAAAAAAGAS SKDTILPGTV SSASSTSSAA GGTSSLFEEM
HTHMLLYGES GKVVDLARAE TAFRILTALL APRGATGNRM LLNCLVSSGT TTTSDSSAEH
SLVELMNRHV RAILGQHFWS APASDEEKHK HITLLELLIT ISLHFLRSYF LNSPISPVTE
ADLTSLWKCK ISALEFLCEL FRELSAMLNE HESKQFVQFV QTILNRSKLQ KCILHLLLTA
VDHNPMESSS SKKTGGGGGP LSVSISKFNE GLLGESRRLS PLLAAYHRSL LTFTSHAIRL
ECDIKRGFAT FSDANSSHRF SIIQSVMNQS FNNRTSRVDN HASTVELRAF LLILLNALKK
QPHRHEMWLQ FVVQILPWVE RSLATIVCRV VEQLCKNMEN AMSVAYENPP TSDVVVDSPG
DVRDEPDCYP ANYLAMTMEL LTTLVHFCVI DSVPTSAVAG GAPGVGGAGG VTSSSGGVQQ
VIHENATPTP SSTSMVGHAM SVIPGSKVAT ELFSQLGKVF SMSGDSGGVI SKLDSSRQHG
NGWRQAQSDM LSSLPHSLAT ICNVWTVVRR AQPPIVPIGT NSQLRRLVLH LLSPIAQYHK
HAFLTSLALV WLTRSTAKPT VTLRKQDPDR ATFEYSSAQL DITNLLLSLQ VIPFEDLISS
VNSTLREASF KANKVGITTI DKANFPTEEP LLELVHSCVS AVLQTQLRLC WSSLLSLFSE
APLSALSARA VFLLFVILSD FVKCVGGAYI VEDKAMYRNV QEVCSRLAEA VNAIVGWQLE
TTTWLKRTLV VKQDHGSSIS SSIRSVDQSP IIEIQSSMSN VSGGGGSLDN PSGSTRNSTL
SLINKPGGSI GTGSSVTSTL VDSKSENMKI EKKSSSNLRA SIKDTNNNRR DPAHSTQALF
LLAERLTDLL DSVSKSDEKD KVLPTLQAVW ANVVPYLKAK NARNARFFLA SSQLLASMSS
YSYMRPVWKK TTLDLLLDSG FFKMDHSALK QWLVVTDHLM THDRTSFKDL LKSISYSPNT
SFSIMTSKEQ EYEARAQALK RLTFVVFGSQ LDQYHGQMND IQERLSDNLR VSQSPVIRSA
VFLCIRVLLL RLRPHSLIGV WPIMVTELVH ALSQLEQQLQ SGEQDSGATA ASSDQWMQLY
VAACKLLETL CTLPAGYLSH FQMFHWAFVS SVSADKTEIF KPFAERINDL LAKKYGELLT
PETMSNHTAS LGAVKILTSF EELRPFFYTL ANLNKSVPES NNTLRDAHAL SGSLTYKNAV
ARLESALYVD FSEHLQF
