ID   PADA_DICDI              Reviewed;         301 AA.
AC   Q54LW0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Prestalk A differentiation protein A;
GN   Name=padA; ORFNames=DDB_G0286385;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in development and cell differentiation.
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000085; EAL64217.2; -; Genomic_DNA.
DR   RefSeq; XP_637720.2; XM_632628.2.
DR   AlphaFoldDB; Q54LW0; -.
DR   SMR; Q54LW0; -.
DR   STRING; 44689.DDB0266469; -.
DR   PaxDb; Q54LW0; -.
DR   EnsemblProtists; EAL64217; EAL64217; DDB_G0286385.
DR   GeneID; 8625585; -.
DR   KEGG; ddi:DDB_G0286385; -.
DR   dictyBase; DDB_G0286385; padA.
DR   eggNOG; ENOG502S8P8; Eukaryota.
DR   HOGENOM; CLU_007383_10_6_1; -.
DR   InParanoid; Q54LW0; -.
DR   OMA; WFMQNFS; -.
DR   PhylomeDB; Q54LW0; -.
DR   PRO; PR:Q54LW0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0051287; F:NAD binding; ISS:dictyBase.
DR   GO; GO:0070402; F:NADPH binding; ISS:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR   GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR   GO; GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF13460; NAD_binding_10; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..301
FT                   /note="Prestalk A differentiation protein A"
FT                   /id="PRO_0000343638"
SQ   SEQUENCE   301 AA;  33705 MW;  A1F7960149C5DFB3 CRC64;
     MQTNITSTKM SILVTGGTGV VGRQVVKSLE LREKNINIRV GGRDQDKCNQ LGFGKNSTFT
     RFDFMDPTTW DKSLEGVDRV FLIALPMDPT PEKSLGPFIE KCKERKLKKI VVLSVIDAER
     VPLVKIEQMV QGSGLTFVIL RPPFFSENFS EGFMKHDIDQ GTIRVPVGEH SVNWISTHDI
     GECASIVLMD SKFDGRTIEI TGPKPINFKE LSEVVSKNVG KQIRFEDIKP QEYKKCLMDR
     GISEPSANYL NELFTSARED KLSKCTKGVN EITGHDPRSF EQFAKETFSN TSGSCTSKPV
     I