PADC1_DROME
ID PADC1_DROME Reviewed; 196 AA.
AC Q9W1W9;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=PRADC1-like protein;
DE AltName: Full=PAP21-like protein;
DE Flags: Precursor;
GN ORFNames=CG9849;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP POSSIBLE FUNCTION.
RX PubMed=14550529; DOI=10.1016/s0925-4773(03)00182-5;
RA Bidet Y., Jagla T., Da Ponte J.-P., Dastugue B., Jagla K.;
RT "Modifiers of muscle and heart cell fate specification identified by gain-
RT of-function screen in Drosophila.";
RL Mech. Dev. 120:991-1007(2003).
CC -!- FUNCTION: May be involved in iversification of muscle cell fates.
CC {ECO:0000305|PubMed:14550529}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9BSG0}.
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DR EMBL; AE013599; AAF46933.1; -; Genomic_DNA.
DR EMBL; AY071051; AAL48673.1; -; mRNA.
DR RefSeq; NP_001188993.1; NM_001202064.2.
DR RefSeq; NP_611740.1; NM_137896.3.
DR AlphaFoldDB; Q9W1W9; -.
DR SMR; Q9W1W9; -.
DR GlyGen; Q9W1W9; 1 site.
DR PaxDb; Q9W1W9; -.
DR PRIDE; Q9W1W9; -.
DR DNASU; 37647; -.
DR EnsemblMetazoa; FBtr0071951; FBpp0071862; FBgn0034803.
DR EnsemblMetazoa; FBtr0302895; FBpp0292026; FBgn0034803.
DR GeneID; 37647; -.
DR KEGG; dme:Dmel_CG9849; -.
DR UCSC; CG9849-RA; d. melanogaster.
DR FlyBase; FBgn0034803; CG9849.
DR VEuPathDB; VectorBase:FBgn0034803; -.
DR eggNOG; KOG3920; Eukaryota.
DR GeneTree; ENSGT00390000009837; -.
DR HOGENOM; CLU_084006_2_0_1; -.
DR InParanoid; Q9W1W9; -.
DR OMA; KINHPPW; -.
DR OrthoDB; 1302890at2759; -.
DR PhylomeDB; Q9W1W9; -.
DR BioGRID-ORCS; 37647; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37647; -.
DR PRO; PR:Q9W1W9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034803; Expressed in spermathecum and 23 other tissues.
DR ExpressionAtlas; Q9W1W9; baseline and differential.
DR Genevisible; Q9W1W9; DM.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0007521; P:muscle cell fate determination; IMP:UniProtKB.
DR CDD; cd02127; PA_hPAP21_like; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR042773; PADC1.
DR InterPro; IPR037323; PRADC1-like_PA.
DR PANTHER; PTHR22702; PTHR22702; 1.
DR Pfam; PF02225; PA; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..196
FT /note="PRADC1-like protein"
FT /id="PRO_0000022000"
FT DOMAIN 73..171
FT /note="PA"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 21551 MW; 657C6A4010C4B189 CRC64;
MLIAWLVLAA TLSRSIRAST TISIPITTQD IIAGDVFFEI LSPSELEYTY RLRPAKDFGS
AFSERLEGVP LVITDPPGAC QEIRNARDLN GGVALIDRGE CSFLTKTLRA EAAGALAAII
TEYNPSSPEF EHYIEMIHDN SQQDANIPAG FLLGKNGVII RSTLQRLKRV HALINIPVNL
TFTPPSKINH PPWLGW
