ID   PAEA_HAEIN              Reviewed;         432 AA.
AC   P44717;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Polyamine export protein {ECO:0000250|UniProtKB:A0A0F6BAS6};
GN   Name=paeA {ECO:0000250|UniProtKB:A0A0F6BAS6}; OrderedLocusNames=HI_0452;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in cadaverine and putrescine tolerance in stationary
CC       phase. May facilitate the efflux of both cadaverine and putrescine from
CC       the cytoplasm, reducing potentially toxic levels under certain stress
CC       conditions. {ECO:0000250|UniProtKB:A0A0F6BAS6}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AE45}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. PaeA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22110.1; -; Genomic_DNA.
DR   PIR; H64152; H64152.
DR   RefSeq; NP_438613.1; NC_000907.1.
DR   RefSeq; WP_010868987.1; NC_000907.1.
DR   AlphaFoldDB; P44717; -.
DR   SMR; P44717; -.
DR   STRING; 71421.HI_0452; -.
DR   EnsemblBacteria; AAC22110; AAC22110; HI_0452.
DR   KEGG; hin:HI_0452; -.
DR   PATRIC; fig|71421.8.peg.472; -.
DR   eggNOG; COG1253; Bacteria.
DR   HOGENOM; CLU_015237_4_0_6; -.
DR   OMA; YLTMEDV; -.
DR   PhylomeDB; P44717; -.
DR   BioCyc; HINF71421:G1GJ1-468-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..432
FT                   /note="Polyamine export protein"
FT                   /id="PRO_0000088365"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..201
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          220..279
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          286..345
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   432 AA;  48708 MW;  828EBD30B046D96B CRC64;
     MIMELFHTIL AIVALILSSA VVSSAEISLA SPRKLKLQSL ANKGDVRPLQ VLKLQEHPGR
     FITVVQILLN MVAILGGGIG ESALSPYIAD ILNRSFEGSW IAPTASTIAF ILVTCLFILF
     ADLIPKRIAI TYPEMVALSV VGIMNFSMYV FKPLVWFFDT IANVFFRLFR ISTVREDGMT
     SEDIFAVVEA GAEAGVLKTQ EHYLIENIFD MQARTVTSTM TTRENIVYLD RTFSRQEVMD
     TLSRDSHSKI VICDNGLDKI LGYIESHTLL TMYLQNENVV LTDPKLLRKA LFVPDTLSLY
     EVLELFKSTG EDFAIIVNEY ALVVGIVTLN DVMSIVMGEL VSNEEEYIVS RDENSWLIDG
     ATPLEEVTRV LDIAYFPDEE NYETISGFMM YMLRKIPKKT DSVVYGKYKF EVIDTENFKI
     DQILVSLVKE QE