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PAF15_XENTR
ID   PAF15_XENTR             Reviewed;         125 AA.
AC   Q6AZL2;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=PCNA-associated factor {ECO:0000305};
DE   AltName: Full=PCNA-associated factor of 15 kDa;
DE            Short=PAF15;
DE            Short=p15PAF;
DE   AltName: Full=PCNA-clamp-associated factor {ECO:0000250|UniProtKB:Q15004};
GN   Name=pclaf {ECO:0000250|UniProtKB:Q15004}; Synonyms=paf;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair
CC       during DNA replication. Following DNA damage, the interaction with pcna
CC       is disrupted, facilitating the interaction between monoubiquitinated
CC       pcna and the translesion DNA synthesis DNA polymerase eta (polh) at
CC       stalled replisomes, facilitating the bypass of replication-fork-
CC       blocking lesions. Also acts as a regulator of centrosome number (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with pcna. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15004}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15004}.
CC       Note=Following DNA damage, localizes to DNA damage sites. Colocalizes
CC       with centrosomes in perinuclear region. {ECO:0000250|UniProtKB:Q15004}.
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DR   EMBL; AAMC01085630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC077667; AAH77667.1; -; mRNA.
DR   RefSeq; NP_001005130.1; NM_001005130.2.
DR   AlphaFoldDB; Q6AZL2; -.
DR   SMR; Q6AZL2; -.
DR   STRING; 8364.ENSXETP00000057278; -.
DR   PaxDb; Q6AZL2; -.
DR   DNASU; 448713; -.
DR   Ensembl; ENSXETT00000057278; ENSXETP00000057278; ENSXETG00000027460.
DR   GeneID; 448713; -.
DR   KEGG; xtr:448713; -.
DR   CTD; 9768; -.
DR   Xenbase; XB-GENE-1006964; pclaf.
DR   eggNOG; ENOG502S3UM; Eukaryota.
DR   HOGENOM; CLU_142343_0_0_1; -.
DR   InParanoid; Q6AZL2; -.
DR   OMA; NRCISDS; -.
DR   OrthoDB; 1508906at2759; -.
DR   PhylomeDB; Q6AZL2; -.
DR   TreeFam; TF333199; -.
DR   Reactome; R-XTR-5656169; Termination of translesion DNA synthesis.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027460; Expressed in 2-cell stage embryo and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0009411; P:response to UV; ISS:UniProtKB.
DR   GO; GO:0019985; P:translesion synthesis; ISS:UniProtKB.
DR   InterPro; IPR040444; PCNA-AF.
DR   InterPro; IPR031444; PCNA-AF_dom.
DR   PANTHER; PTHR15679; PTHR15679; 1.
DR   Pfam; PF15715; PAF; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..125
FT                   /note="PCNA-associated factor"
FT                   /id="PRO_0000420483"
FT   REGION          1..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           28..39
FT                   /note="D-box"
FT   MOTIF           68..79
FT                   /note="PIP-box"
FT   MOTIF           85..87
FT                   /note="KEN box"
FT   MOTIF           95..107
FT                   /note="Initiation motif"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   125 AA;  12885 MW;  72B3D8CD184ED6C2 CRC64;
     MVRTKADSAG SSASSGSYRK AVAARAPRKT FGSSSSGSNH VTSPTGKKSE SKYAGGNPVC
     VRPTPTWQKG IGEFFGSPST SQPEKENRIP SDDEEAGGSG AGKAPRKSRP LPPDPSEEAA
     DSDDE
 
 
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