ID   PAF1_XENTR              Reviewed;         520 AA.
AC   Q6P2Y1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=RNA polymerase II-associated factor 1 homolog;
GN   Name=paf1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple
CC       functions during transcription by RNA polymerase II. PAF1C associates
CC       with RNA polymerase II, is involved in transcriptional elongation and
CC       in histone modifications including methylation on histone H3 'Lys-4'
CC       (H3K4me3) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex
CC       interacts with PHF5A (By similarity). {ECO:0000250|UniProtKB:Q8K2T8,
CC       ECO:0000250|UniProtKB:Q8N7H5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PAF1 family. {ECO:0000305}.
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DR   EMBL; BC064253; AAH64253.1; -; mRNA.
DR   RefSeq; NP_989348.1; NM_204017.1.
DR   AlphaFoldDB; Q6P2Y1; -.
DR   SMR; Q6P2Y1; -.
DR   DNASU; 394974; -.
DR   Ensembl; ENSXETT00000006351; ENSXETP00000006351; ENSXETG00000002902.
DR   GeneID; 394974; -.
DR   KEGG; xtr:394974; -.
DR   CTD; 54623; -.
DR   Xenbase; XB-GENE-5797651; paf1.
DR   InParanoid; Q6P2Y1; -.
DR   OrthoDB; 599989at2759; -.
DR   Reactome; R-XTR-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-XTR-75955; RNA Polymerase II Transcription Elongation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002902; Expressed in gastrula and 13 other tissues.
DR   ExpressionAtlas; Q6P2Y1; baseline.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0016570; P:histone modification; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   InterPro; IPR007133; RNA_pol_II-assoc_Paf1.
DR   PANTHER; PTHR23188; PTHR23188; 1.
DR   Pfam; PF03985; Paf1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..520
FT                   /note="RNA polymerase II-associated factor 1 homolog"
FT                   /id="PRO_0000326406"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          351..447
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        359..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..390
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..434
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..474
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  59065 MW;  76D526C423C459A7 CRC64;
     MAPTIQTQAQ REDGHRSSSH RTVPERSGVV CRVKYCNTLP DIPFDPKFIT YPFDQNRFVQ
     YKATSLEKQH KHDLLTEPDL GVTIDLINPD TYRIDPNVTL DIADEKLLEE EIQAPSSSKR
     SQQHAKVVPW MRKTEYISTE FNRYGVSNEK PEVKIGVSVK QQFTEEDIYK DRDSQISAIE
     KTFEDAQKPI SQHYSKPRVT PVEVMPVFPD FKMWINPCAQ VIFDSDPAPK DASGSAALDM
     MSQAMIRGMM DEEGNQFVAY FLPGEETMRK RKRDQEEGLD YMPEDIYDYK IAREYNWNVK
     NKASKGYEEN YFFIFREGDG VYYNELETRV RLSKRRVKAG VQSGTNAVLV VKHRDMHEKE
     LEAQEARRAQ LENHEPEEEE EIEVDQETQG SDAEDGEKGS GSEKEGSGAE QSGSESEREE
     AEEEEKEDEE EKESSEEDRA ARDKEEIFGS DDDDSDEDGP NESGQDGEDS GSDDEEEKGQ
     GRRSRSASSS PFGSDHSQQE NEDQSASDQG SGSSTGSDSD