PAG15_CANLF
ID PAG15_CANLF Reviewed; 408 AA.
AC Q6XPZ3;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Phospholipase A2 group XV {ECO:0000250|UniProtKB:Q8VEB4};
DE AltName: Full=1-O-acylceramide synthase {ECO:0000303|PubMed:11790796};
DE Short=ACS {ECO:0000303|PubMed:11790796};
DE AltName: Full=LCAT-like lysophospholipase {ECO:0000303|PubMed:11790796};
DE Short=LLPL {ECO:0000303|PubMed:11790796};
DE EC=3.1.1.5 {ECO:0000250|UniProtKB:Q8NCC3};
DE AltName: Full=Lysophospholipase 3;
DE AltName: Full=Lysosomal phospholipase A and acyltransferase;
DE EC=2.3.1.- {ECO:0000269|PubMed:11790796};
DE EC=3.1.1.32 {ECO:0000250|UniProtKB:Q8VEB4};
DE EC=3.1.1.4 {ECO:0000250|UniProtKB:Q8VEB4};
DE AltName: Full=Lysosomal phospholipase A2 {ECO:0000250|UniProtKB:Q8VEB4};
DE Short=LPLA2 {ECO:0000250|UniProtKB:Q8VEB4};
DE Flags: Precursor;
GN Name=PLA2G15; Synonyms=LYPLA3;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION, AND CATALYTIC
RP ACTIVITY.
RX PubMed=11790796; DOI=10.1074/jbc.m111977200;
RA Hiraoka M., Abe A., Shayman J.A.;
RT "Cloning and characterization of a lysosomal phospholipase A2, 1-O-
RT acylceramide synthase.";
RL J. Biol. Chem. 277:10090-10099(2002).
CC -!- FUNCTION: Has dual calcium-independent phospholipase and O-
CC acyltransferase activities with a potential role in glycerophospholipid
CC homeostasis and remodeling of acyl groups of lipophilic alcohols
CC present in acidic cellular compartments (PubMed:11790796). Catalyzes
CC hydrolysis of the ester bond of the fatty acyl group attached at sn-1
CC or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and
CC transfer it to the hydroxyl group at the first carbon of lipophilic
CC alcohols (O-acyltransferase activity) (PubMed:11790796). Among
CC preferred fatty acyl donors are phosphatidylcholines,
CC phosphatidylethanolamines, phosphatidylglycerols and
CC phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated
CC fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines
CC (By similarity). Among preferred fatty acyl acceptors are natural
CC lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine
CC (C2 ceramide), alkylacylglycerols, monoacylglycerols, and
CC acylethanolamides such as anandamide and oleoylethanolamide (By
CC similarity). Selectively hydrolyzes the sn-1 fatty acyl group of
CC truncated oxidized phospholipids and may play a role in detoxification
CC of reactive oxidized phospholipids during oxidative stress. Required
CC for normal phospholipid degradation in alveolar macrophages with
CC potential implications in pulmonary surfactant clearance (By
CC similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the
CC lysophosphatidylcholines (By similarity).
CC {ECO:0000250|UniProtKB:Q8NCC3, ECO:0000250|UniProtKB:Q8VEB4,
CC ECO:0000269|PubMed:11790796}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O =
CC 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62480, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:77756, ChEBI:CHEBI:145781;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62481;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O =
CC 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62464, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:78207, ChEBI:CHEBI:145780;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62465;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62484, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77890,
CC ChEBI:CHEBI:145782; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62485;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine +
CC H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62488, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042,
CC ChEBI:CHEBI:145783; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62489;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-
CC phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) +
CC hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435,
CC ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16870, ChEBI:CHEBI:72998;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38827, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73007, ChEBI:CHEBI:76077, ChEBI:CHEBI:76088;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38828;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-
CC octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38823, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73007, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38824;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38831, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73008, ChEBI:CHEBI:76077, ChEBI:CHEBI:76090;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38832;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38835, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73008, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38836;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38843,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73009, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76091; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38844;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-
CC (5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-
CC hexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38839,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009,
CC ChEBI:CHEBI:76080; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38840;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38759, ChEBI:CHEBI:46979, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38760;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38755, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38756;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine; Xref=Rhea:RHEA:38811, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73002, ChEBI:CHEBI:76077, ChEBI:CHEBI:76084;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38812;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:38807, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38808;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38775, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73003, ChEBI:CHEBI:76077, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38776;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38771, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38772;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-
CC docosahexaenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38815,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:74963, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76085; Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38816;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine +
CC 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38819,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963,
CC ChEBI:CHEBI:76087; Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38820;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine +
CC 2-nonadioyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:62472,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:76077, ChEBI:CHEBI:78207,
CC ChEBI:CHEBI:145780; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62473;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38799, ChEBI:CHEBI:46979, ChEBI:CHEBI:75034,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38800;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38795, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858,
CC ChEBI:CHEBI:75034, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38796;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:57108, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:76086, ChEBI:CHEBI:84822;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57109;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57120, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74965, ChEBI:CHEBI:76074, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57121;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57116, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:74965, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57117;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38767, ChEBI:CHEBI:46979, ChEBI:CHEBI:74667,
CC ChEBI:CHEBI:76054, ChEBI:CHEBI:76078;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38768;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38763, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74667, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38764;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38791, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76076;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38792;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38803, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38804;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-
CC enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38703, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000269|PubMed:11790796};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38704;
CC Evidence={ECO:0000305|PubMed:11790796};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine;
CC Xref=Rhea:RHEA:57140, ChEBI:CHEBI:46979, ChEBI:CHEBI:76074,
CC ChEBI:CHEBI:77342, ChEBI:CHEBI:78260;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57141;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-
CC sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine;
CC Xref=Rhea:RHEA:57136, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:78260, ChEBI:CHEBI:84467;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57137;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57144, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72845, ChEBI:CHEBI:76074, ChEBI:CHEBI:141490;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57145;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-
CC (acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57148, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72827, ChEBI:CHEBI:72845, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57149;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-
CC glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-
CC eicosatetraenoylamino]ethyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38751,
CC ChEBI:CHEBI:2700, ChEBI:CHEBI:74669, ChEBI:CHEBI:76070,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38752;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-
CC octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate;
CC Xref=Rhea:RHEA:38747, ChEBI:CHEBI:71466, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:76068, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38748;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38743, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75938, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38744;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38739, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75757, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38740;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-
CC hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol; Xref=Rhea:RHEA:38735,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:75455, ChEBI:CHEBI:76065,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38736;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38731, ChEBI:CHEBI:64757, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:75867, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38732;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O =
CC (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38707, ChEBI:CHEBI:74669, ChEBI:CHEBI:75936,
CC ChEBI:CHEBI:76055, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38708;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:38711,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76061, ChEBI:CHEBI:76062,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38712;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38723, ChEBI:CHEBI:74669, ChEBI:CHEBI:76063,
CC ChEBI:CHEBI:76064, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38724;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38727, ChEBI:CHEBI:74669, ChEBI:CHEBI:75542,
CC ChEBI:CHEBI:75868, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38728;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8NCC3}. Lysosome
CC {ECO:0000269|PubMed:11790796}. Membrane {ECO:0000250|UniProtKB:Q8NCC3};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NCC3}.
CC -!- PTM: N-glycosylated. N-glycosylation is important for maturation of the
CC enzyme and normal subcellular location. {ECO:0000250|UniProtKB:Q8NCC3}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000255}.
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DR EMBL; AY217754; AAO91807.1; -; mRNA.
DR RefSeq; NP_001002940.1; NM_001002940.1.
DR AlphaFoldDB; Q6XPZ3; -.
DR SMR; Q6XPZ3; -.
DR STRING; 9612.ENSCAFP00000030134; -.
DR ESTHER; canfa-q6xpz3; PC-sterol_acyltransferase.
DR PaxDb; Q6XPZ3; -.
DR PRIDE; Q6XPZ3; -.
DR Ensembl; ENSCAFT00030027995; ENSCAFP00030024434; ENSCAFG00030015158.
DR Ensembl; ENSCAFT00040022114; ENSCAFP00040019185; ENSCAFG00040011998.
DR Ensembl; ENSCAFT00845020534; ENSCAFP00845016103; ENSCAFG00845011578.
DR GeneID; 403403; -.
DR KEGG; cfa:403403; -.
DR CTD; 23659; -.
DR VEuPathDB; HostDB:ENSCAFG00845011578; -.
DR eggNOG; KOG2369; Eukaryota.
DR GeneTree; ENSGT00940000157499; -.
DR HOGENOM; CLU_037070_1_1_1; -.
DR InParanoid; Q6XPZ3; -.
DR OMA; PNENKQF; -.
DR OrthoDB; 828056at2759; -.
DR TreeFam; TF313258; -.
DR Reactome; R-CFA-1483115; Hydrolysis of LPC.
DR Proteomes; UP000002254; Chromosome 5.
DR Bgee; ENSCAFG00000020318; Expressed in placenta and 49 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005764; C:lysosome; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0052740; F:1-acyl-2-lysophosphatidylserine acylhydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0016411; F:acylglycerol O-acyltransferase activity; ISS:UniProtKB.
DR GO; GO:0047499; F:calcium-independent phospholipase A2 activity; ISS:UniProtKB.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0008374; F:O-acyltransferase activity; ISS:UniProtKB.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0052739; F:phosphatidylserine 1-acylhydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0008970; F:phospholipase A1 activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR GO; GO:0006651; P:diacylglycerol biosynthetic process; ISS:UniProtKB.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; ISS:UniProtKB.
DR GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR GO; GO:0034638; P:phosphatidylcholine catabolic process; ISS:UniProtKB.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; ISS:UniProtKB.
DR GO; GO:0046338; P:phosphatidylethanolamine catabolic process; ISS:UniProtKB.
DR GO; GO:0046471; P:phosphatidylglycerol metabolic process; ISS:UniProtKB.
DR GO; GO:0006658; P:phosphatidylserine metabolic process; ISS:UniProtKB.
DR Gene3D; 3.40.50.1820; -; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR Pfam; PF02450; LCAT; 2.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Disulfide bond; Fatty acid metabolism; Glycoprotein;
KW Hydrolase; Lipid metabolism; Lysosome; Membrane; Metal-binding;
KW Reference proteome; Secreted; Signal; Transferase; Zinc.
FT SIGNAL 1..31
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT CHAIN 32..408
FT /note="Phospholipase A2 group XV"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT /id="PRO_0000413419"
FT ACT_SITE 194
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3, ECO:0000255"
FT ACT_SITE 356
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT ACT_SITE 388
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 42
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 194
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 195
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 336
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 351
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 388
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 61..85
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
SQ SEQUENCE 408 AA; 46031 MW; B7B5CF4EFDC0BF42 CRC64;
MGLRRGPCPA ALLPGGFLFL LLLADPALLA GRRPPVVLVP GDLGNQLEAK LDKPTVVHYL
CSKRTESYFT LWLNLELLLP VIIDCWIDNI RLVYNRTSRA TQFPDGVDVR VPGFGKTFSL
EFLDPSKSSV GSYFHTMVES LVDWGYIRGE DVRGAPYDWR RAPNENGPYF LALREMIEEM
YQLYGGPVVL VAHSMGNMYT LYFLQRQPQA WKNKYIQAFV ALGAPWGGVA KTLRVLASGD
NNRIPVIRPL KIREQQRSAV STSWLLPYNY TWSPEKIFVH TPTANYTLRD YHQFFQDIGF
KDGWLMRQDT EGLVEAMVPP GVPLHCLYGT GVPTPDSFYY ESFPDRDPKI CFGDGDGTVN
LQSALQCQAW RGHQEHQVSL QALPGSEHIE MLANATTLAY LKRVLLGP
