PAG15_RAT
ID PAG15_RAT Reviewed; 413 AA.
AC Q675A5;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Phospholipase A2 group XV {ECO:0000250|UniProtKB:Q8VEB4};
DE AltName: Full=1-O-acylceramide synthase {ECO:0000303|PubMed:15294901};
DE Short=ACS {ECO:0000303|PubMed:15294901};
DE AltName: Full=LCAT-like lysophospholipase {ECO:0000250|UniProtKB:Q8NCC3};
DE Short=LLPL {ECO:0000250|UniProtKB:Q8NCC3};
DE EC=3.1.1.5 {ECO:0000250|UniProtKB:Q8NCC3};
DE AltName: Full=Lysophospholipase 3;
DE AltName: Full=Lysosomal phospholipase A and acyltransferase;
DE EC=2.3.1.- {ECO:0000269|PubMed:15294901};
DE EC=3.1.1.32 {ECO:0000250|UniProtKB:Q8VEB4};
DE EC=3.1.1.4 {ECO:0000250|UniProtKB:Q8VEB4};
DE AltName: Full=Lysosomal phospholipase A2 {ECO:0000303|PubMed:15294901};
DE Short=LPLA2 {ECO:0000303|PubMed:15294901};
DE Flags: Precursor;
GN Name=Pla2g15; Synonyms=Lypla3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, ACTIVITY
RP REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar;
RX PubMed=15294901; DOI=10.1074/jbc.m407834200;
RA Abe A., Hiraoka M., Wild S., Wilcoxen S.E., Paine R., Shayman J.A.;
RT "Lysosomal phospholipase A2 is selectively expressed in alveolar
RT macrophages.";
RL J. Biol. Chem. 279:42605-42611(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Brown Norway; TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has dual calcium-independent phospholipase and O-
CC acyltransferase activities with a potential role in glycerophospholipid
CC homeostasis and remodeling of acyl groups of lipophilic alcohols
CC present in acidic cellular compartments (PubMed:15294901). Catalyzes
CC hydrolysis of the ester bond of the fatty acyl group attached at sn-1
CC or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and
CC transfer it to the hydroxyl group at the first carbon of lipophilic
CC alcohols (O-acyltransferase activity) (PubMed:15294901). Among
CC preferred fatty acyl donors are phosphatidylcholines,
CC phosphatidylethanolamines, phosphatidylglycerols and
CC phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated
CC fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines
CC (By similarity). Among preferred fatty acyl acceptors are natural
CC lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine
CC (C2 ceramide), alkylacylglycerols, monoacylglycerols, and
CC acylethanolamides such as anandamide and oleoylethanolamide (By
CC similarity). Selectively hydrolyzes the sn-1 fatty acyl group of
CC truncated oxidized phospholipids and may play a role in detoxification
CC of reactive oxidized phospholipids during oxidative stress. Required
CC for normal phospholipid degradation in alveolar macrophages with
CC potential implications in pulmonary surfactant clearance (By
CC similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the
CC lysophosphatidylcholines (By similarity).
CC {ECO:0000250|UniProtKB:Q8NCC3, ECO:0000250|UniProtKB:Q8VEB4,
CC ECO:0000269|PubMed:15294901}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O =
CC 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62480, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:77756, ChEBI:CHEBI:145781;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62481;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O =
CC 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62464, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:78207, ChEBI:CHEBI:145780;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62465;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62484, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77890,
CC ChEBI:CHEBI:145782; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62485;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine +
CC H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62488, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042,
CC ChEBI:CHEBI:145783; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62489;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-
CC phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) +
CC hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435,
CC ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16870, ChEBI:CHEBI:72998;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38827, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73007, ChEBI:CHEBI:76077, ChEBI:CHEBI:76088;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38828;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-
CC octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38823, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73007, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38824;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38831, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73008, ChEBI:CHEBI:76077, ChEBI:CHEBI:76090;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38832;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38835, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73008, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38836;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38843,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73009, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76091; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38844;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-
CC (5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-
CC hexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38839,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009,
CC ChEBI:CHEBI:76080; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38840;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38759, ChEBI:CHEBI:46979, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38760;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38755, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38756;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine; Xref=Rhea:RHEA:38811, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73002, ChEBI:CHEBI:76077, ChEBI:CHEBI:76084;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38812;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:38807, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38808;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38775, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73003, ChEBI:CHEBI:76077, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38776;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38771, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38772;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-
CC docosahexaenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38815,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:74963, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76085; Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38816;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine +
CC 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38819,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963,
CC ChEBI:CHEBI:76087; Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38820;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine +
CC 2-nonadioyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:62472,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:76077, ChEBI:CHEBI:78207,
CC ChEBI:CHEBI:145780; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62473;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38799, ChEBI:CHEBI:46979, ChEBI:CHEBI:75034,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38800;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38795, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858,
CC ChEBI:CHEBI:75034, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38796;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:57108, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:76086, ChEBI:CHEBI:84822;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57109;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57120, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74965, ChEBI:CHEBI:76074, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57121;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57116, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:74965, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57117;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38767, ChEBI:CHEBI:46979, ChEBI:CHEBI:74667,
CC ChEBI:CHEBI:76054, ChEBI:CHEBI:76078;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38768;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38763, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74667, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38764;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38791, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76076;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38792;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38803, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38804;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-
CC enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38703, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000269|PubMed:15294901};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38704;
CC Evidence={ECO:0000305|PubMed:15294901};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine;
CC Xref=Rhea:RHEA:57140, ChEBI:CHEBI:46979, ChEBI:CHEBI:76074,
CC ChEBI:CHEBI:77342, ChEBI:CHEBI:78260;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57141;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-
CC sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine;
CC Xref=Rhea:RHEA:57136, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:78260, ChEBI:CHEBI:84467;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57137;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57144, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72845, ChEBI:CHEBI:76074, ChEBI:CHEBI:141490;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57145;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-
CC (acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57148, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72827, ChEBI:CHEBI:72845, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57149;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-
CC glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-
CC eicosatetraenoylamino]ethyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38751,
CC ChEBI:CHEBI:2700, ChEBI:CHEBI:74669, ChEBI:CHEBI:76070,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38752;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-
CC octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate;
CC Xref=Rhea:RHEA:38747, ChEBI:CHEBI:71466, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:76068, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38748;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38743, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75938, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38744;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38739, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75757, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38740;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-
CC hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol; Xref=Rhea:RHEA:38735,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:75455, ChEBI:CHEBI:76065,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38736;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38731, ChEBI:CHEBI:64757, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:75867, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38732;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O =
CC (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38707, ChEBI:CHEBI:74669, ChEBI:CHEBI:75936,
CC ChEBI:CHEBI:76055, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38708;
CC Evidence={ECO:0000250|UniProtKB:Q8NCC3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:38711,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76061, ChEBI:CHEBI:76062,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38712;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38723, ChEBI:CHEBI:74669, ChEBI:CHEBI:76063,
CC ChEBI:CHEBI:76064, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38724;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38727, ChEBI:CHEBI:74669, ChEBI:CHEBI:75542,
CC ChEBI:CHEBI:75868, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38728;
CC Evidence={ECO:0000250|UniProtKB:Q8VEB4};
CC -!- ACTIVITY REGULATION: Transacylase activity is inhibited by MJ33.
CC {ECO:0000269|PubMed:15294901}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Optimum pH is 4.5. {ECO:0000269|PubMed:15294901};
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q6XPZ3}. Secreted
CC {ECO:0000250|UniProtKB:Q8NCC3}. Membrane
CC {ECO:0000250|UniProtKB:Q8NCC3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q8NCC3}.
CC -!- TISSUE SPECIFICITY: Detected in alveolar macrophages (at protein
CC level). Widely expressed. Expressed at highest levels in alveolar
CC macrophages. {ECO:0000269|PubMed:15294901}.
CC -!- PTM: N-glycosylated. N-glycosylation is important for maturation of the
CC enzyme and normal subcellular location. {ECO:0000250|UniProtKB:Q8NCC3}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY490816; AAS66767.1; -; mRNA.
DR EMBL; CH473972; EDL92440.1; -; Genomic_DNA.
DR EMBL; BC098894; AAH98894.1; -; mRNA.
DR RefSeq; NP_001004277.1; NM_001004277.2.
DR AlphaFoldDB; Q675A5; -.
DR SMR; Q675A5; -.
DR STRING; 10116.ENSRNOP00000026996; -.
DR ESTHER; ratno-q675a5; PC-sterol_acyltransferase.
DR GlyGen; Q675A5; 4 sites.
DR PaxDb; Q675A5; -.
DR Ensembl; ENSRNOT00000026996; ENSRNOP00000026996; ENSRNOG00000019859.
DR GeneID; 361401; -.
DR KEGG; rno:361401; -.
DR UCSC; RGD:1302982; rat.
DR CTD; 23659; -.
DR RGD; 1302982; Pla2g15.
DR eggNOG; KOG2369; Eukaryota.
DR GeneTree; ENSGT00940000157499; -.
DR HOGENOM; CLU_037070_1_1_1; -.
DR InParanoid; Q675A5; -.
DR OMA; PNENKQF; -.
DR OrthoDB; 828056at2759; -.
DR PhylomeDB; Q675A5; -.
DR TreeFam; TF313258; -.
DR Reactome; R-RNO-1483115; Hydrolysis of LPC.
DR PRO; PR:Q675A5; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Proteomes; UP000234681; Chromosome 19.
DR Bgee; ENSRNOG00000019859; Expressed in spleen and 19 other tissues.
DR Genevisible; Q675A5; RN.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0052740; F:1-acyl-2-lysophosphatidylserine acylhydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0016411; F:acylglycerol O-acyltransferase activity; ISS:UniProtKB.
DR GO; GO:0047499; F:calcium-independent phospholipase A2 activity; IDA:RGD.
DR GO; GO:0008374; F:O-acyltransferase activity; IDA:UniProtKB.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0052739; F:phosphatidylserine 1-acylhydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0008970; F:phospholipase A1 activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0006672; P:ceramide metabolic process; IDA:UniProtKB.
DR GO; GO:0006651; P:diacylglycerol biosynthetic process; ISS:UniProtKB.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; ISS:UniProtKB.
DR GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR GO; GO:0034638; P:phosphatidylcholine catabolic process; ISS:UniProtKB.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IMP:RGD.
DR GO; GO:0046338; P:phosphatidylethanolamine catabolic process; ISS:UniProtKB.
DR GO; GO:0046471; P:phosphatidylglycerol metabolic process; ISS:UniProtKB.
DR GO; GO:0006658; P:phosphatidylserine metabolic process; ISS:UniProtKB.
DR Gene3D; 3.40.50.1820; -; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Disulfide bond; Fatty acid metabolism; Glycoprotein;
KW Hydrolase; Lipid metabolism; Lysosome; Membrane; Metal-binding;
KW Reference proteome; Secreted; Signal; Transferase; Zinc.
FT SIGNAL 1..33
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT CHAIN 34..413
FT /note="Phospholipase A2 group XV"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413420"
FT ACT_SITE 198
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3, ECO:0000255"
FT ACT_SITE 360
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT ACT_SITE 392
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 46
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 198
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 199
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 355
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT BINDING 392
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..89
FT /evidence="ECO:0000250|UniProtKB:Q8NCC3"
SQ SEQUENCE 413 AA; 47391 MW; A9CCED59B8B50957 CRC64;
MDRHLCICRE IQLRSGLLFP FLLLMMLADL ALPAQRHPPV VLVPGDLGNQ LEAKLDKPKV
VHYLCSKRTD SYFTLWLNLE LLLPVIIDCW IDNIRLVYNR TSRTTQFPDG VDVRVPGFGE
TFSLEFLDPS KRNVGSYFYT MVESLVGWGY TRGEDVRGAP YDWRRAPNEN GPYFLALQEM
IEEMYQMYGG PVVLVAHSMG NMYMLYFLQR QPQAWKDKYI QAFVSLGAPW GGVAKTLRVL
ASGDNNRIPV IGPLKIREQQ RSAVSTSWLL PYNHTWSHEK VFVYTPTANY TLRDYHRFFQ
DIGFEDGWFM RQDTQGLVEA LVPPGVELHC LYGTGVPTPN SFYYENFPDR DPKICFGDGD
GTVNLESVLQ CQAWQSRQEH KVSLQELPGS EHIEMLANAT TLAYLKRVLL EEP
