ID   PAGC_SALTY              Reviewed;         185 AA.
AC   P23988;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Virulence membrane protein PagC;
DE   Flags: Precursor;
GN   Name=pagC; OrderedLocusNames=STM1246;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=1846140; DOI=10.1128/jb.173.1.86-93.1991;
RA   Pulkkinen W.S., Miller S.I.;
RT   "A Salmonella typhimurium virulence protein is similar to a Yersinia
RT   enterocolitica invasion protein and a bacteriophage lambda outer membrane
RT   protein.";
RL   J. Bacteriol. 173:86-93(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Essential for full virulence and survival within macrophages.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       Ail family. {ECO:0000305}.
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DR   EMBL; M55546; AAA27179.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20174.1; -; Genomic_DNA.
DR   PIR; A39185; A39185.
DR   RefSeq; NP_460215.1; NC_003197.2.
DR   RefSeq; WP_000789471.1; NC_003197.2.
DR   AlphaFoldDB; P23988; -.
DR   SMR; P23988; -.
DR   STRING; 99287.STM1246; -.
DR   PaxDb; P23988; -.
DR   EnsemblBacteria; AAL20174; AAL20174; STM1246.
DR   GeneID; 1252764; -.
DR   KEGG; stm:STM1246; -.
DR   PATRIC; fig|99287.12.peg.1318; -.
DR   HOGENOM; CLU_099385_1_0_6; -.
DR   OMA; NIRGVNA; -.
DR   PhylomeDB; P23988; -.
DR   BioCyc; SENT99287:STM1246-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044384; C:host outer membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000758; Enterovir_OMP.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   Pfam; PF06316; Ail_Lom; 1.
DR   PRINTS; PR00316; ENTEROVIROMP.
DR   SUPFAM; SSF56925; SSF56925; 1.
DR   PROSITE; PS00694; ENT_VIR_OMP_1; 1.
DR   PROSITE; PS00695; ENT_VIR_OMP_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..185
FT                   /note="Virulence membrane protein PagC"
FT                   /id="PRO_0000020204"
FT   CONFLICT        33
FT                   /note="A -> ARYA (in Ref. 1; AAA27179)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   185 AA;  20184 MW;  10B4E785032ECB9E CRC64;
     MKNIILSTLV ITTSVLVVNV AQADTNAFSV GYAQSKVQDF KNIRGVNVKY RYEDDSPVSF
     ISSLSYLYGD RQASGSVEPE GIHYHDKFEV KYGSLMVGPA YRLSDNFSLY ALAGVGTVKA
     TFKEHSTQDG DSFSNKISSR KTGFAWGAGV QMNPLENIVV DVGYEGSNIS STKINGFNVG
     VGYRF