PAGE1_HUMAN
ID PAGE1_HUMAN Reviewed; 146 AA.
AC O75459; Q6FGM3; Q9BSS7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=P antigen family member 1;
DE Short=PAGE-1;
DE AltName: Full=AL5;
DE AltName: Full=G antigen 9;
DE Short=GAGE-9;
DE AltName: Full=G antigen family B member 1;
DE AltName: Full=Prostate-associated gene 1 protein;
GN Name=PAGE1; Synonyms=GAGE9, GAGEB1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-75.
RX PubMed=9651357; DOI=10.1074/jbc.273.28.17618;
RA Chen M.E., Lin S.-H., Chung L.W.K., Sikes R.A.;
RT "Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed
RT in the LNCaP prostate cancer progression model that share homology with
RT melanoma-associated antigens.";
RL J. Biol. Chem. 273:17618-17625(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-144, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-105, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC O75459; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-2559100, EBI-2807956;
CC O75459; Q9Y6V7: DDX49; NbExp=3; IntAct=EBI-2559100, EBI-719274;
CC O75459; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-2559100, EBI-10175124;
CC O75459; O14880: MGST3; NbExp=3; IntAct=EBI-2559100, EBI-724754;
CC O75459; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-2559100, EBI-10485931;
CC O75459; P43005: SLC1A1; NbExp=3; IntAct=EBI-2559100, EBI-745376;
CC O75459; P22732: SLC2A5; NbExp=3; IntAct=EBI-2559100, EBI-2825135;
CC O75459; P02786: TFRC; NbExp=3; IntAct=EBI-2559100, EBI-355727;
CC O75459; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2559100, EBI-8638294;
CC O75459; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-2559100, EBI-11956809;
CC O75459; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-2559100, EBI-2852148;
CC O75459; P01375: TNF; NbExp=3; IntAct=EBI-2559100, EBI-359977;
CC -!- TISSUE SPECIFICITY: Isolated from prostate cancer cell lines;
CC expression associated with progression to androgen insensitive
CC phenotype. Expressed in normal testis and at lower level in normal
CC placenta.
CC -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC large variety of tumors whereas in normal tissues, expression is
CC restricted to germ cells. These genes organized in clustered repeats,
CC have a high degree of predicted sequence identity, but differ by
CC scattered single nucleotide substitution. Their sequences contain
CC either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. {ECO:0000305}.
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DR EMBL; AF058989; AAC25990.1; -; mRNA.
DR EMBL; CR542084; CAG46881.1; -; mRNA.
DR EMBL; AC231643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004861; AAH04861.1; -; mRNA.
DR CCDS; CCDS14327.1; -.
DR RefSeq; NP_003776.2; NM_003785.3.
DR RefSeq; XP_011542300.1; XM_011543998.2.
DR AlphaFoldDB; O75459; -.
DR BioGRID; 114254; 94.
DR IntAct; O75459; 13.
DR STRING; 9606.ENSP00000365320; -.
DR iPTMnet; O75459; -.
DR PhosphoSitePlus; O75459; -.
DR BioMuta; PAGE1; -.
DR EPD; O75459; -.
DR MassIVE; O75459; -.
DR MaxQB; O75459; -.
DR PaxDb; O75459; -.
DR PeptideAtlas; O75459; -.
DR PRIDE; O75459; -.
DR ProteomicsDB; 50020; -.
DR Antibodypedia; 487; 199 antibodies from 22 providers.
DR DNASU; 8712; -.
DR Ensembl; ENST00000376150.4; ENSP00000365320.3; ENSG00000068985.5.
DR GeneID; 8712; -.
DR KEGG; hsa:8712; -.
DR MANE-Select; ENST00000376150.4; ENSP00000365320.3; NM_003785.4; NP_003776.2.
DR UCSC; uc004dom.4; human.
DR CTD; 8712; -.
DR DisGeNET; 8712; -.
DR GeneCards; PAGE1; -.
DR HGNC; HGNC:4107; PAGE1.
DR HPA; ENSG00000068985; Tissue enriched (testis).
DR MIM; 300288; gene.
DR neXtProt; NX_O75459; -.
DR OpenTargets; ENSG00000068985; -.
DR PharmGKB; PA28522; -.
DR VEuPathDB; HostDB:ENSG00000068985; -.
DR eggNOG; ENOG502SZ68; Eukaryota.
DR GeneTree; ENSGT00940000153097; -.
DR HOGENOM; CLU_150116_0_0_1; -.
DR InParanoid; O75459; -.
DR OMA; QDSTQEG; -.
DR OrthoDB; 1483716at2759; -.
DR PhylomeDB; O75459; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; O75459; -.
DR SignaLink; O75459; -.
DR BioGRID-ORCS; 8712; 16 hits in 699 CRISPR screens.
DR ChiTaRS; PAGE1; human.
DR GenomeRNAi; 8712; -.
DR Pharos; O75459; Tbio.
DR PRO; PR:O75459; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O75459; protein.
DR Bgee; ENSG00000068985; Expressed in right testis and 33 other tissues.
DR Genevisible; O75459; HS.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 3.
DR Pfam; PF05831; GAGE; 2.
DR SMART; SM01379; GAGE; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..146
FT /note="P antigen family member 1"
FT /id="PRO_0000148347"
FT REGION 16..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VARIANT 75
FT /note="L -> P (in dbSNP:rs1055197)"
FT /evidence="ECO:0000269|PubMed:9651357"
FT /id="VAR_027767"
SQ SEQUENCE 146 AA; 16150 MW; E6C7BA94D898DCB2 CRC64;
MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG ASAAQGQEPE
ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE PEADSQEQVH PKTGCERGDG
PDVQELGLPN PEEVKTPEED EGQSQP
