ID   PAGE2_HUMAN             Reviewed;         111 AA.
AC   Q7Z2X7; Q5JRK7; Q5JRK8;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=P antigen family member 2;
DE            Short=PAGE-2;
DE   AltName: Full=G antigen family C 2;
DE   AltName: Full=Prostate-associated gene 2 protein;
GN   Name=PAGE2; Synonyms=GAGEC2, GAGEE2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q7Z2X7; P50222: MEOX2; NbExp=3; IntAct=EBI-10256818, EBI-748397;
CC       Q7Z2X7; Q9BSI4: TINF2; NbExp=2; IntAct=EBI-10256818, EBI-717399;
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR   EMBL; AL590240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC054022; AAH54022.1; -; mRNA.
DR   CCDS; CCDS14367.1; -.
DR   RefSeq; NP_997222.1; NM_207339.3.
DR   RefSeq; XP_016884842.1; XM_017029353.1.
DR   AlphaFoldDB; Q7Z2X7; -.
DR   SMR; Q7Z2X7; -.
DR   BioGRID; 128479; 8.
DR   IntAct; Q7Z2X7; 6.
DR   STRING; 9606.ENSP00000364107; -.
DR   iPTMnet; Q7Z2X7; -.
DR   PhosphoSitePlus; Q7Z2X7; -.
DR   BioMuta; PAGE2; -.
DR   DMDM; 74750038; -.
DR   EPD; Q7Z2X7; -.
DR   MassIVE; Q7Z2X7; -.
DR   MaxQB; Q7Z2X7; -.
DR   PaxDb; Q7Z2X7; -.
DR   PeptideAtlas; Q7Z2X7; -.
DR   PRIDE; Q7Z2X7; -.
DR   ProteomicsDB; 68984; -.
DR   Antibodypedia; 62243; 24 antibodies from 11 providers.
DR   DNASU; 203569; -.
DR   Ensembl; ENST00000374968.9; ENSP00000364107.4; ENSG00000234068.7.
DR   GeneID; 203569; -.
DR   KEGG; hsa:203569; -.
DR   MANE-Select; ENST00000374968.9; ENSP00000364107.4; NM_207339.4; NP_997222.1.
DR   UCSC; uc004duf.2; human.
DR   CTD; 203569; -.
DR   GeneCards; PAGE2; -.
DR   HGNC; HGNC:31804; PAGE2.
DR   HPA; ENSG00000234068; Tissue enriched (testis).
DR   MIM; 300738; gene.
DR   neXtProt; NX_Q7Z2X7; -.
DR   OpenTargets; ENSG00000234068; -.
DR   PharmGKB; PA142671202; -.
DR   VEuPathDB; HostDB:ENSG00000234068; -.
DR   eggNOG; ENOG502TF3A; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   InParanoid; Q7Z2X7; -.
DR   OMA; AFQGPDM; -.
DR   OrthoDB; 1551004at2759; -.
DR   PhylomeDB; Q7Z2X7; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q7Z2X7; -.
DR   SignaLink; Q7Z2X7; -.
DR   BioGRID-ORCS; 203569; 12 hits in 608 CRISPR screens.
DR   GenomeRNAi; 203569; -.
DR   Pharos; Q7Z2X7; Tdark.
DR   PRO; PR:Q7Z2X7; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q7Z2X7; protein.
DR   Bgee; ENSG00000234068; Expressed in right testis and 88 other tissues.
DR   ExpressionAtlas; Q7Z2X7; baseline and differential.
DR   Genevisible; Q7Z2X7; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..111
FT                   /note="P antigen family member 2"
FT                   /id="PRO_0000247362"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         5
FT                   /note="L -> V (in dbSNP:rs1845444)"
FT                   /id="VAR_053099"
SQ   SEQUENCE   111 AA;  12090 MW;  C0692E3DF2C905F8 CRC64;
     MSELLRARSQ SSERGNDQES SQPVGSVIVQ EPTEEKRQEE EPPTDNQGIA PSGEIENQAV
     PAFQGPDMEA FQQELALLKI EDEPGDGPDV REGIMPTFDL TKVLEAGDAQ P