PAGE3_HUMAN
ID PAGE3_HUMAN Reviewed; 113 AA.
AC Q5JUK9; A5D6Y1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=P antigen family member 3;
DE Short=PAGE-3;
DE AltName: Full=G antigen family D member 1;
DE AltName: Full=Prostate-associated gene 3 protein;
GN Name=PAGE3; Synonyms=GAGED1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-35.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-35.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JUK9; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-10244544, EBI-10175124;
CC Q5JUK9; P50221: MEOX1; NbExp=3; IntAct=EBI-10244544, EBI-2864512;
CC Q5JUK9; O43765: SGTA; NbExp=6; IntAct=EBI-10244544, EBI-347996;
CC Q5JUK9; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-10244544, EBI-744081;
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR EMBL; AL158819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471154; EAW93220.1; -; Genomic_DNA.
DR EMBL; BC140001; AAI40002.1; -; mRNA.
DR EMBL; BC140741; AAI40742.1; -; mRNA.
DR EMBL; BC144449; AAI44450.1; -; mRNA.
DR CCDS; CCDS35307.1; -.
DR RefSeq; NP_001017931.2; NM_001017931.2.
DR RefSeq; NP_001164723.1; NM_001171252.1.
DR RefSeq; NP_001290542.1; NM_001303613.1.
DR RefSeq; XP_016884771.1; XM_017029282.1.
DR AlphaFoldDB; Q5JUK9; -.
DR IntAct; Q5JUK9; 4.
DR STRING; 9606.ENSP00000364089; -.
DR BioMuta; PAGE3; -.
DR DMDM; 74742310; -.
DR PaxDb; Q5JUK9; -.
DR PRIDE; Q5JUK9; -.
DR Antibodypedia; 71531; 33 antibodies from 15 providers.
DR DNASU; 139793; -.
DR Ensembl; ENST00000374951.6; ENSP00000364089.1; ENSG00000204279.8.
DR Ensembl; ENST00000519203.1; ENSP00000429571.1; ENSG00000204279.8.
DR GeneID; 139793; -.
DR KEGG; hsa:139793; -.
DR MANE-Select; ENST00000374951.6; ENSP00000364089.1; NM_001017931.3; NP_001017931.3.
DR UCSC; uc022bxs.4; human.
DR CTD; 139793; -.
DR GeneCards; PAGE3; -.
DR HGNC; HGNC:4110; PAGE3.
DR HPA; ENSG00000204279; Tissue enriched (testis).
DR MIM; 300739; gene.
DR neXtProt; NX_Q5JUK9; -.
DR VEuPathDB; HostDB:ENSG00000204279; -.
DR eggNOG; ENOG502TF3A; Eukaryota.
DR GeneTree; ENSGT00940000153097; -.
DR HOGENOM; CLU_150116_2_0_1; -.
DR InParanoid; Q5JUK9; -.
DR OMA; ENQDYTP; -.
DR OrthoDB; 1551004at2759; -.
DR PhylomeDB; Q5JUK9; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; Q5JUK9; -.
DR SignaLink; Q5JUK9; -.
DR BioGRID-ORCS; 139793; 2 hits in 197 CRISPR screens.
DR GenomeRNAi; 139793; -.
DR Pharos; Q5JUK9; Tdark.
DR PRO; PR:Q5JUK9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JUK9; protein.
DR Bgee; ENSG00000204279; Expressed in right testis and 19 other tissues.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..113
FT /note="P antigen family member 3"
FT /id="PRO_0000247360"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 35
FT /note="N -> D (in dbSNP:rs4826381)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_027097"
FT VARIANT 53
FT /note="G -> S (in dbSNP:rs2296807)"
FT /id="VAR_027098"
SQ SEQUENCE 113 AA; 12480 MW; D46910FC698E09B2 CRC64;
MSGHQRTRSR SRERRDDQDS NHPVGAVVAQ ELPSNDQLQQ EEPPIESQDY TPGQERDEGA
LDFQVLGLAA YLWELTRSKT GGERGDGPNV KGEFLPNLEP VKIPEAGEGQ PSV
