PAGE5_HUMAN
ID PAGE5_HUMAN Reviewed; 130 AA.
AC Q96GU1; Q2NL97; Q5JUL0; Q8WWL9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=P antigen family member 5;
DE Short=PAGE-5;
DE AltName: Full=Cancer/testis antigen 16.1;
DE Short=CT16.1;
DE AltName: Full=G antigen family E member 1;
DE AltName: Full=Prostate-associated gene 5 protein;
GN Name=PAGE5; Synonyms=GAGEE1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11992404; DOI=10.1002/ijc.10371;
RA Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA van Muijen G.N.P.;
RT "The XAGE family of cancer/testis-associated genes: alignment and
RT expression profile in normal tissues, melanoma lesions and Ewing's
RT sarcoma.";
RL Int. J. Cancer 99:361-369(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113 AND THR-116, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96GU1; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11305258, EBI-16439278;
CC Q96GU1; Q9NUX5: POT1; NbExp=2; IntAct=EBI-11305258, EBI-752420;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96GU1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96GU1-2; Sequence=VSP_042547;
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR EMBL; AJ344352; CAC87642.1; -; mRNA.
DR EMBL; AL158819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009230; AAH09230.2; -; mRNA.
DR EMBL; BC110803; AAI10804.2; -; mRNA.
DR CCDS; CCDS14368.1; -. [Q96GU1-1]
DR CCDS; CCDS35306.1; -. [Q96GU1-2]
DR RefSeq; NP_001013453.1; NM_001013435.2. [Q96GU1-2]
DR RefSeq; NP_569734.2; NM_130467.4. [Q96GU1-1]
DR AlphaFoldDB; Q96GU1; -.
DR BioGRID; 124758; 14.
DR IntAct; Q96GU1; 2.
DR STRING; 9606.ENSP00000289619; -.
DR iPTMnet; Q96GU1; -.
DR PhosphoSitePlus; Q96GU1; -.
DR BioMuta; PAGE5; -.
DR DMDM; 74751892; -.
DR MassIVE; Q96GU1; -.
DR MaxQB; Q96GU1; -.
DR PaxDb; Q96GU1; -.
DR PeptideAtlas; Q96GU1; -.
DR PRIDE; Q96GU1; -.
DR ProteomicsDB; 76666; -. [Q96GU1-1]
DR ProteomicsDB; 76667; -. [Q96GU1-2]
DR Antibodypedia; 64478; 72 antibodies from 13 providers.
DR DNASU; 90737; -.
DR Ensembl; ENST00000289619.9; ENSP00000289619.5; ENSG00000158639.13. [Q96GU1-1]
DR Ensembl; ENST00000374955.8; ENSP00000364093.3; ENSG00000158639.13. [Q96GU1-2]
DR GeneID; 90737; -.
DR KEGG; hsa:90737; -.
DR MANE-Select; ENST00000374955.8; ENSP00000364093.3; NM_001013435.3; NP_001013453.1. [Q96GU1-2]
DR UCSC; uc004duj.4; human. [Q96GU1-1]
DR CTD; 90737; -.
DR DisGeNET; 90737; -.
DR GeneCards; PAGE5; -.
DR HGNC; HGNC:29992; PAGE5.
DR HPA; ENSG00000158639; Tissue enriched (testis).
DR MIM; 301009; gene.
DR neXtProt; NX_Q96GU1; -.
DR OpenTargets; ENSG00000158639; -.
DR PharmGKB; PA142671204; -.
DR VEuPathDB; HostDB:ENSG00000158639; -.
DR eggNOG; ENOG502TF3A; Eukaryota.
DR GeneTree; ENSGT00940000153097; -.
DR InParanoid; Q96GU1; -.
DR OMA; GNMSGHV; -.
DR OrthoDB; 1551004at2759; -.
DR PhylomeDB; Q96GU1; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; Q96GU1; -.
DR SignaLink; Q96GU1; -.
DR BioGRID-ORCS; 90737; 14 hits in 691 CRISPR screens.
DR GenomeRNAi; 90737; -.
DR Pharos; Q96GU1; Tbio.
DR PRO; PR:Q96GU1; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96GU1; protein.
DR Bgee; ENSG00000158639; Expressed in left testis and 81 other tissues.
DR ExpressionAtlas; Q96GU1; baseline and differential.
DR Genevisible; Q96GU1; HS.
DR DisProt; DP01473; -.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..130
FT /note="P antigen family member 5"
FT /id="PRO_0000247361"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 113
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 116
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..20
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042547"
SQ SEQUENCE 130 AA; 14046 MW; 17560A128E103424 CRC64;
MQAPWAGNRG WAGTREEVRD MSEHVTRSQS SERGNDQESS QPVGPVIVQQ PTEEKRQEEE
PPTDNQGIAP SGEIKNEGAP AVQGTDVEAF QQELALLKIE DAPGDGPDVR EGTLPTFDPT
KVLEAGEGQL
