ID   PAGO_SALTY              Reviewed;         304 AA.
AC   O30646;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Protein PagO;
GN   Name=pagO; OrderedLocusNames=STM1862;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9712687; DOI=10.1006/mpat.1998.0217;
RA   Gunn J.S., Belden W.J., Miller S.I.;
RT   "Identification of PhoP-PhoQ activated genes within a duplicated region of
RT   the Salmonella typhimurium chromosome.";
RL   Microb. Pathog. 25:77-90(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR   EMBL; AF013775; AAB82452.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20777.1; -; Genomic_DNA.
DR   RefSeq; NP_460818.1; NC_003197.2.
DR   RefSeq; WP_001233446.1; NC_003197.2.
DR   AlphaFoldDB; O30646; -.
DR   SMR; O30646; -.
DR   STRING; 99287.STM1862; -.
DR   TCDB; 2.A.7.3.25; the drug/metabolite transporter (dmt) superfamily.
DR   PaxDb; O30646; -.
DR   EnsemblBacteria; AAL20777; AAL20777; STM1862.
DR   GeneID; 1253381; -.
DR   KEGG; stm:STM1862; -.
DR   PATRIC; fig|99287.12.peg.1972; -.
DR   HOGENOM; CLU_033863_5_3_6; -.
DR   OMA; FKGLDPM; -.
DR   PhylomeDB; O30646; -.
DR   BioCyc; SENT99287:STM1862-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..304
FT                   /note="Protein PagO"
FT                   /id="PRO_0000108150"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          15..139
FT                   /note="EamA 1"
FT   DOMAIN          161..287
FT                   /note="EamA 2"
SQ   SEQUENCE   304 AA;  33622 MW;  B368153FD6EBFB0B CRC64;
     MRKVSISILF MLVSLTWGTT WLAMRIAVET IPPVFATGMR FMFAAPFLII IAWLRKKTLL
     FPPGQRLFQF VICIFYFCIP FSLMIYGETY VNSGLAAIIF ANMPVAVLIA SVLFLNEKAK
     LMQIAGLTIA ITALTGILLE ETNTSTESHW QGITALISAV LIHAIIYTQC KKRSCTVSVI
     TFNALPCLLA GLILSATGWF FERPQVSTFS VHSILATLYL GAFAGVFGIL CYFALQQKAN
     AFQASLVFLI FPLIAVSLED YIYGYAISTH SMLLIIPLVI GIFLTLVARN LPVTSRCRDN
     SSQK