PAGR1_BOVIN
ID PAGR1_BOVIN Reviewed; 253 AA.
AC Q1LZ80; A4FV67;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=PAXIP1-associated glutamate-rich protein 1;
DE AltName: Full=PAXIP1-associated protein 1;
DE AltName: Full=PTIP-associated protein 1;
GN Name=PAGR1; Synonyms=PA1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia, and Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Its association with the histone methyltransferase MLL2/MLL3
CC complex is suggesting a role in epigenetic transcriptional activation.
CC However, in association with PAXIP1/PTIP is proposed to function at
CC least in part independently of the MLL2/MLL3 complex. Proposed to be
CC recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1
CC complex is required for cell survival in response to DNA damage
CC independently of the MLL2/MLL3 complex. However, its function in DNA
CC damage has been questioned. During immunoglobulin class switching in
CC activated B-cells is involved in transcription regulation of downstream
CC switch regions at the immunoglobulin heavy-chain (Igh) locus
CC independently of the MLL2/MLL3 complex. Involved in both estrogen
CC receptor-regulated gene transcription and estrogen-stimulated G1/S
CC cell-cycle transition. Acts as transcriptional cofactor for nuclear
CC hormone receptors. Inhibits the induction properties of several steroid
CC receptors such as NR3C1, AR and PPARG; the mechanism of inhibition
CC appears to be gene-dependent. {ECO:0000250|UniProtKB:Q99L02,
CC ECO:0000250|UniProtKB:Q9BTK6}.
CC -!- SUBUNIT: Component of the KMT2 family MLL2/MLL3 complex, at least
CC composed of the histone methyltransferases KMT2D and/or KMT2C, the
CC common complex subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex
CC type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is
CC required for the association with the MLL2/MLL3 complex (By
CC similarity). Forms a constitutive complex with PAXIP1/PTIP
CC independently of the MLL2/MLL3 complex. Interacts with NCOA1, ESR1,
CC NR3C1, AR. {ECO:0000250|UniProtKB:Q99L02,
CC ECO:0000250|UniProtKB:Q9BTK6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99L02,
CC ECO:0000250|UniProtKB:Q9BTK6}.
CC -!- CAUTION: The terminology of MLL proteins in mammalia is not consistent
CC also concerning the terminology of MLL protein-containing complexes.
CC The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4
CC complex in literature. {ECO:0000305}.
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DR EMBL; BC116156; AAI16157.1; -; mRNA.
DR EMBL; BC118095; AAI18096.1; -; mRNA.
DR EMBL; BC123802; AAI23803.1; -; mRNA.
DR RefSeq; NP_001069100.1; NM_001075632.1.
DR RefSeq; XP_005224957.1; XM_005224900.3.
DR RefSeq; XP_015315856.1; XM_015460370.1.
DR AlphaFoldDB; Q1LZ80; -.
DR STRING; 9913.ENSBTAP00000014478; -.
DR PaxDb; Q1LZ80; -.
DR PRIDE; Q1LZ80; -.
DR Ensembl; ENSBTAT00000014478; ENSBTAP00000014478; ENSBTAG00000010904.
DR Ensembl; ENSBTAT00000045230; ENSBTAP00000042638; ENSBTAG00000010904.
DR GeneID; 513650; -.
DR KEGG; bta:513650; -.
DR CTD; 79447; -.
DR VEuPathDB; HostDB:ENSBTAG00000010904; -.
DR VGNC; VGNC:97294; PAGR1.
DR eggNOG; ENOG502S0T8; Eukaryota.
DR GeneTree; ENSGT00390000016049; -.
DR HOGENOM; CLU_088613_1_0_1; -.
DR InParanoid; Q1LZ80; -.
DR OMA; QAWMPPP; -.
DR OrthoDB; 1630689at2759; -.
DR TreeFam; TF326621; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000010904; Expressed in anterior segment of eyeball and 106 other tissues.
DR GO; GO:0044666; C:MLL3/4 complex; IBA:GO_Central.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR GO; GO:1902808; P:positive regulation of cell cycle G1/S phase transition; IBA:GO_Central.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR028213; PA1.
DR PANTHER; PTHR28467; PTHR28467; 1.
DR Pfam; PF15364; PAXIP1_C; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..253
FT /note="PAXIP1-associated glutamate-rich protein 1"
FT /id="PRO_0000248333"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..160
FT /note="Sufficient for interaction with NCOA1"
FT /evidence="ECO:0000250|UniProtKB:Q9BTK6"
FT REGION 128..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..253
FT /note="Sufficient for interaction with ESR1"
FT /evidence="ECO:0000250|UniProtKB:Q9BTK6"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 138
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5M865"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M865"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M865"
FT MOD_RES 237
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M865"
SQ SEQUENCE 253 AA; 27784 MW; AC1F399520B92B42 CRC64;
MSLVRGHGDI AATTAAPLSE EGEVTSGLQA LAVEDTGGPS ASADQAEEEG EGGREEAEHE
GSGAEEVQGE APSPEGEERA KGESEDWCVP CSDEEVELPA DGQSWMPPPS EIQRLYELLA
AHGTLELQAE ILPRRPPTPE AQSEEERSDE EPEAKEEEEE KPHMPTEFDF DDEPTTPKDS
LIDRRRTPGS SARSQKREAR LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDASPASPPL
RSSGSLFPRQ RKY
