ID   PAHO_ALLMI              Reviewed;          36 AA.
AC   P06305;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Pancreatic hormone;
DE            Short=PH;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
GN   Name=ppy;
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6745282; DOI=10.1111/j.1432-1033.1984.tb08298.x;
RA   Glover I.D., Barlow D.J., Pitts J.E., Wood S.P., Tickle I.J.,
RA   Blundell T.L., Tatemoto K., Kimmel J.R., Wollmer A., Strassburger W.,
RA   Zhang Y.S.;
RT   "Conformational studies on the pancreatic polypeptide hormone family.";
RL   Eur. J. Biochem. 142:379-385(1984).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=6146554; DOI=10.1016/0016-6480(84)90135-7;
RA   Lance V., Hamilton J.W., Rouse J.B., Kimmel J.R., Pollock H.G.;
RT   "Isolation and characterization of reptilian insulin, glucagon, and
RT   pancreatic polypeptide: complete amino acid sequence of alligator
RT   (Alligator mississippiensis) insulin and pancreatic polypeptide.";
RL   Gen. Comp. Endocrinol. 55:112-124(1984).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A01577; PCAQ.
DR   AlphaFoldDB; P06305; -.
DR   SMR; P06305; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000044807"
FT   MOD_RES         36
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        22
FT                   /note="D -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   36 AA;  4195 MW;  FE96FD2448185D9D CRC64;
     TPLQPKYPGD GAPVEDLIQF YDDLQQYLNV VTRPRF