PAHO_ANSAN
ID PAHO_ANSAN Reviewed; 36 AA.
AC P06304;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Pancreatic hormone;
DE Short=PH;
DE AltName: Full=Pancreatic polypeptide;
DE Short=PP;
GN Name=PPY;
OS Anser anser anser (Western greylag goose).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anserinae; Anser.
OX NCBI_TaxID=8844;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=6484562;
RA Xu Y., Lin N., Zhang Y.S.;
RT "Isolation and sequence determination of goose pancreatic polypeptide.";
RL Sci. Sin., Ser. B Chem. Biol. Agric. Med. Earth Sci. 27:590-592(1984).
RN [2]
RP PROTEIN SEQUENCE.
RX PubMed=6745282; DOI=10.1111/j.1432-1033.1984.tb08298.x;
RA Glover I.D., Barlow D.J., Pitts J.E., Wood S.P., Tickle I.J.,
RA Blundell T.L., Tatemoto K., Kimmel J.R., Wollmer A., Strassburger W.,
RA Zhang Y.S.;
RT "Conformational studies on the pancreatic polypeptide hormone family.";
RL Eur. J. Biochem. 142:379-385(1984).
CC -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC functions.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; A01576; PCGS.
DR AlphaFoldDB; P06304; -.
DR SMR; P06304; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Hormone; Secreted.
FT PEPTIDE 1..36
FT /note="Pancreatic hormone"
FT /id="PRO_0000044803"
FT MOD_RES 36
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250"
FT VARIANT 30
FT /note="N -> V"
SQ SEQUENCE 36 AA; 4391 MW; 32141F4536F427EF CRC64;
GPSQPTYPGN DAPVEDLRFY YDNLQQYRLN VFRHRY