ID   PAHO_BOVIN              Reviewed;         131 AA.
AC   P01302;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE   Contains:
DE     RecName: Full=C-terminal peptide 1;
DE   Contains:
DE     RecName: Full=C-terminal peptide 2;
DE   Flags: Precursor;
GN   Name=PPY;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7831336; DOI=10.1073/pnas.92.2.594;
RA   Herzog H., Hort Y., Schneider R., Shine J.;
RT   "Seminalplasmin: recent evolution of another member of the neuropeptide Y
RT   gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:594-598(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-65, AND AMIDATION AT TYR-65.
RA   Chance R.E., Moon N.E., Johnson M.G.;
RL   (In) Jaffe B.M., Behrman H.R. (eds.);
RL   Methods of hormone radioimmunoassay (2nd ed.), pp.657-672, Academic Press,
RL   New York and London (1979).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=1734969; DOI=10.1021/bi00119a038;
RA   Li X., Sutcliffe M.J., Schwartz T.W., Dodson C.M.;
RT   "Sequence-specific 1H NMR assignments and solution structure of bovine
RT   pancreatic polypeptide.";
RL   Biochemistry 31:1245-1253(1992).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; L33970; AAA98526.1; -; Genomic_DNA.
DR   PIR; A01570; PCBO.
DR   PDB; 1BBA; NMR; -; A=30-65.
DR   PDB; 1LJV; NMR; -; A=30-65.
DR   PDB; 1V1D; NMR; -; A=30-60.
DR   PDBsum; 1BBA; -.
DR   PDBsum; 1LJV; -.
DR   PDBsum; 1V1D; -.
DR   AlphaFoldDB; P01302; -.
DR   BMRB; P01302; -.
DR   SMR; P01302; -.
DR   InParanoid; P01302; -.
DR   EvolutionaryTrace; P01302; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000269|Ref.2"
FT   PEPTIDE         30..65
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000025355"
FT   PEPTIDE         69..89
FT                   /note="C-terminal peptide 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000025356"
FT   PEPTIDE         93..131
FT                   /note="C-terminal peptide 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000025357"
FT   MOD_RES         65
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|Ref.2"
FT   STRAND          38..40
FT                   /evidence="ECO:0007829|PDB:1LJV"
FT   HELIX           45..60
FT                   /evidence="ECO:0007829|PDB:1BBA"
SQ   SEQUENCE   131 AA;  14376 MW;  DCDFE1011C67DF9B CRC64;
     MAAAHRCLFL LLLSTCVALL LQPPLGALGA PLEPEYPGDN ATPEQMAQYA AELRRYINML
     TRPRYGKRDK EGTLDFLECG SPHSAVPRYG KRDKEGTLDF LECGSPHSAV PRWVFSLSCV
     PRCLGQENGG V