ID   PAHO_CANLF              Reviewed;          93 AA.
AC   P01299;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 3.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE   Contains:
DE     RecName: Full=Pancreatic icosapeptide;
DE   Flags: Precursor;
GN   Name=PPY;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3079195; DOI=10.1210/mend-1-6-413;
RA   Toothman P., Paquette T.L.;
RT   "Canine pancreatic polypeptide complementary deoxyribonucleic acid
RT   sequence: pancreatic polypeptide and insulin messenger ribonucleic acid
RT   distribution in the lobes of the pancreas.";
RL   Mol. Endocrinol. 1:413-419(1987).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-65.
RA   Chance R.E., Moon N.E., Johnson M.G.;
RL   (In) Jaffe B.M., Behrman H.R. (eds.);
RL   Methods of hormone radioimmunoassay (2nd ed.), pp.657-672, Academic Press,
RL   New York and London (1979).
RN   [3]
RP   PROTEIN SEQUENCE OF 69-88, AND AMIDATION AT TYR-65.
RX   PubMed=7031480; DOI=10.1038/294589a0;
RA   Schwartz T.W., Tager H.S.;
RT   "Isolation and biogenesis of a new peptide from pancreatic islets.";
RL   Nature 294:589-591(1981).
RN   [4]
RP   PROTEIN SEQUENCE OF 89-93, AND AMIDATION AT TYR-65.
RX   PubMed=3827854; DOI=10.1042/bj2400069;
RA   Nielsen H.V., Gether U., Schwartz T.W.;
RT   "Cat pancreatic eicosapeptide and its biosynthetic intermediate.
RT   Conservation of a monobasic processing site.";
RL   Biochem. J. 240:69-74(1986).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- FUNCTION: The physiological role for the icosapeptide has not yet been
CC       elucidated.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; M35596; AAA30886.1; -; mRNA.
DR   PIR; A40904; PCDG.
DR   RefSeq; NP_001300805.1; NM_001313876.1.
DR   AlphaFoldDB; P01299; -.
DR   SMR; P01299; -.
DR   STRING; 9615.ENSCAFP00000021236; -.
DR   PaxDb; P01299; -.
DR   GeneID; 490944; -.
DR   KEGG; cfa:490944; -.
DR   CTD; 5539; -.
DR   eggNOG; ENOG502TD4B; Eukaryota.
DR   HOGENOM; CLU_165150_1_0_1; -.
DR   InParanoid; P01299; -.
DR   OMA; LGFLEWG; -.
DR   TreeFam; TF332778; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000269|Ref.2"
FT   PEPTIDE         30..65
FT                   /note="Pancreatic hormone"
FT                   /evidence="ECO:0000269|PubMed:3079195"
FT                   /id="PRO_0000025358"
FT   PEPTIDE         69..88
FT                   /note="Pancreatic icosapeptide"
FT                   /evidence="ECO:0000269|PubMed:3827854"
FT                   /id="PRO_0000025359"
FT   PROPEP          89..93
FT                   /id="PRO_0000025360"
FT   MOD_RES         65
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:3827854,
FT                   ECO:0000269|PubMed:7031480"
SQ   SEQUENCE   93 AA;  10427 MW;  B88D6D1F0281F413 CRC64;
     MPAACRCLFL LLLSACVALL LQPPLGTRGA PLEPVYPGDD ATPEQMAQYA AELRRYINML
     TRPRYGKRDR GEMRDILEWG SPHAAAPREL MDE