ID   PAHO_CAVPO              Reviewed;         126 AA.
AC   P13083;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE              Short=PH;
DE   Contains:
DE     RecName: Full=Pancreatic icosapeptide-like;
DE   Flags: Precursor;
GN   Name=PPY;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING, AND AMIDATION.
RX   PubMed=2830269; DOI=10.1016/s0021-9258(18)69155-0;
RA   Blackstone C.D., Seino S., Takeuchi T., Yamada T., Steiner D.F.;
RT   "Novel organization and processing of the guinea pig pancreatic polypeptide
RT   precursor.";
RL   J. Biol. Chem. 263:2911-2916(1988).
RN   [2]
RP   PROTEIN SEQUENCE OF 27-62.
RC   TISSUE=Pancreas;
RX   PubMed=3575148; DOI=10.1016/0196-9781(87)90181-1;
RA   Eng J., Huang C.-G., Pan Y.-C., Hulmes J.D., Yalow R.S.;
RT   "Guinea pig pancreatic polypeptide: structure and pancreatic content.";
RL   Peptides 8:165-168(1987).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: No icosapeptide-like peptide is cleaved from the C-terminal.
CC       {ECO:0000269|PubMed:2830269}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; M29543; AAA37051.1; -; mRNA.
DR   PIR; A28256; A28256.
DR   RefSeq; NP_001166476.1; NM_001173005.1.
DR   AlphaFoldDB; P13083; -.
DR   STRING; 10141.ENSCPOP00000014525; -.
DR   GeneID; 100135605; -.
DR   KEGG; cpoc:100135605; -.
DR   CTD; 5539; -.
DR   eggNOG; ENOG502TD4B; Eukaryota.
DR   InParanoid; P13083; -.
DR   OrthoDB; 1586326at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:3575148"
FT   PEPTIDE         27..62
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000025361"
FT   PEPTIDE         65..126
FT                   /note="Pancreatic icosapeptide-like"
FT                   /id="PRO_0000025362"
FT   REGION          77..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         62
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   126 AA;  13489 MW;  76C131560F566326 CRC64;
     MTATRCCLWL LLLGTCMALL LPEAWGAPLE PVYPGDDATP QQMAQYAAEM RRYINMLTRP
     RYGKSAEEDA LGLPVWRQSH AAAPGGSHRH PPAGLPAAKG GTGVSGSPPK PWDCLPCRAH
     SLPSQS