PAHO_CHICK
ID PAHO_CHICK Reviewed; 80 AA.
AC P68248; P01306;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Pancreatic hormone;
DE AltName: Full=Pancreatic polypeptide;
DE Short=PP;
DE Flags: Precursor;
GN Name=PPY;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Liver;
RX PubMed=8359685; DOI=10.1016/0378-1119(93)90418-3;
RA Nata K., Sugimoto T., Kohri K., Hidaka H., Hattori E., Yamamoto H.,
RA Yonekura H., Okamoto H.;
RT "Structure determination and evolution of the chicken cDNA and gene
RT encoding prepropancreatic polypeptide.";
RL Gene 130:183-189(1993).
RN [2]
RP PROTEIN SEQUENCE OF 26-61.
RC TISSUE=Pancreas;
RX PubMed=1194289; DOI=10.1016/s0021-9258(19)40653-4;
RA Kimmel J.R., Hayden L.J., Pollock H.G.;
RT "Isolation and characterization of a new pancreatic polypeptide hormone.";
RL J. Biol. Chem. 250:9369-9376(1975).
CC -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC functions.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR EMBL; D13761; BAA02907.1; -; Genomic_DNA.
DR EMBL; D13760; BAA02906.1; -; mRNA.
DR PIR; JN0776; PCCH.
DR RefSeq; NP_990117.1; NM_204786.1.
DR AlphaFoldDB; P68248; -.
DR BMRB; P68248; -.
DR SMR; P68248; -.
DR STRING; 9031.ENSGALP00000042719; -.
DR Ensembl; ENSGALT00000049554; ENSGALP00000043946; ENSGALG00000039125.
DR GeneID; 395564; -.
DR KEGG; gga:395564; -.
DR CTD; 5539; -.
DR VEuPathDB; HostDB:geneid_395564; -.
DR eggNOG; ENOG502S267; Eukaryota.
DR GeneTree; ENSGT00950000185319; -.
DR HOGENOM; CLU_165150_1_0_1; -.
DR InParanoid; P68248; -.
DR OMA; LGFLEWG; -.
DR OrthoDB; 1606313at2759; -.
DR PhylomeDB; P68248; -.
DR PRO; PR:P68248; -.
DR Proteomes; UP000000539; Chromosome 27.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:1194289"
FT CHAIN 26..61
FT /note="Pancreatic hormone"
FT /id="PRO_0000025376"
FT PROPEP 65..80
FT /id="PRO_0000025377"
FT MOD_RES 61
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250"
FT CONFLICT 47..48
FT /note="ND -> DN (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 80 AA; 8773 MW; 90B44E27389DB050 CRC64;
MPPRWASLLL LACSLLLLAV PPGTAGPSQP TYPGDDAPVE DLIRFYNDLQ QYLNVVTRHR
YGRRSSSRVL CEEPMGAAGC
