ID   PAHO_EQUZE              Reviewed;          36 AA.
AC   P68009; P38000;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Pancreatic hormone;
DE            Short=PH;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
GN   Name=PPY;
OS   Equus zebra (Mountain zebra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9791;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC   TISSUE=Pancreas;
RX   PubMed=1808025; DOI=10.1016/0016-6480(91)90093-l;
RA   Henry J.S., Lance V.A., Conlon J.M.;
RT   "Primary structure of pancreatic polypeptide from four species of
RT   Perissodactyla (Przewalski's horse, zebra, rhino, tapir).";
RL   Gen. Comp. Endocrinol. 84:440-446(1991).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A61132; A61132.
DR   AlphaFoldDB; P68009; -.
DR   SMR; P68009; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000044798"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:1808025"
SQ   SEQUENCE   36 AA;  4215 MW;  761ADA6CC1A6308F CRC64;
     APMEPVYPGD NATPEQMAQY AAELRRYINM LTRPRY