ID   PAHO_MELGA              Reviewed;          36 AA.
AC   P68249; P01306;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Pancreatic hormone;
DE            Short=PH;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
GN   Name=PPY;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   PROTEIN SEQUENCE, AND CRYSTALLIZATION.
RC   TISSUE=Pancreas;
RX   PubMed=913391; DOI=10.1111/j.1432-1033.1977.tb11720.x;
RA   Wood S.P., Pitts J.E., Blundell T.L., Tickle I.J., Jenkins J.A.;
RT   "Purification, crystallisation and preliminary X-ray studies on avian
RT   pancreatic polypeptide.";
RL   Eur. J. Biochem. 78:119-126(1977).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
RX   PubMed=16593056; DOI=10.1073/pnas.78.7.4175;
RA   Blundell T.L., Pitts J.E., Tickle I.J., Wood S.P., Wu C.-W.;
RT   "X-ray analysis (1.4-A resolution) of avian pancreatic polypeptide. Small
RT   globular protein hormone.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4175-4179(1981).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (0.98 ANGSTROMS).
RX   PubMed=6673760; DOI=10.1002/bip.360220138;
RA   Glover I., Maneef I., Pitts J., Woods S.P., Moss D., Tickle I.,
RA   Blundell T.L.;
RT   "Conformational flexibility in a small globular hormone: X-ray analysis of
RT   avian pancreatic polypeptide at 0.98-A resolution.";
RL   Biopolymers 22:293-304(1983).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PDB; 1PPT; X-ray; 1.37 A; A=1-36.
DR   PDB; 2BF9; X-ray; 0.99 A; A=1-35.
DR   PDB; 2H3S; NMR; -; A=1-9, B=13-36.
DR   PDB; 2H3T; NMR; -; A=1-9, B=13-36.
DR   PDB; 2H4B; NMR; -; A/B=1-9, C/D=13-36.
DR   PDBsum; 1PPT; -.
DR   PDBsum; 2BF9; -.
DR   PDBsum; 2H3S; -.
DR   PDBsum; 2H3T; -.
DR   PDBsum; 2H4B; -.
DR   AlphaFoldDB; P68249; -.
DR   BMRB; P68249; -.
DR   SMR; P68249; -.
DR   InParanoid; P68249; -.
DR   EvolutionaryTrace; P68249; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000044805"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   HELIX           14..31
FT                   /evidence="ECO:0007829|PDB:2BF9"
FT   HELIX           32..35
FT                   /evidence="ECO:0007829|PDB:2H3S"
SQ   SEQUENCE   36 AA;  4239 MW;  67840E24949C9BCE CRC64;
     GPSQPTYPGD DAPVEDLIRF YNDLQQYLNV VTRHRY