ID   PAHO_MOUSE              Reviewed;         100 AA.
AC   P10601;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE              Short=PH;
DE   Contains:
DE     RecName: Full=C-terminal peptide;
DE   Flags: Precursor;
GN   Name=Ppy;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=3343236; DOI=10.1016/s0021-9258(18)69165-3;
RA   Yonekura H., Nata K., Watanabe T., Kurashina Y., Yamamoto H., Okamoto H.;
RT   "Mosaic evolution of prepropancreatic polypeptide. II. Structural
RT   conservation and divergence in pancreatic polypeptide gene.";
RL   J. Biol. Chem. 263:2990-2997(1988).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: No icosapeptide-like peptide is cleaved from the C-terminal.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; M18208; AAA39967.1; -; mRNA.
DR   CCDS; CCDS25486.1; -.
DR   PIR; B28261; B28261.
DR   RefSeq; NP_032944.1; NM_008918.1.
DR   AlphaFoldDB; P10601; -.
DR   STRING; 10090.ENSMUSP00000017460; -.
DR   PaxDb; P10601; -.
DR   PRIDE; P10601; -.
DR   ABCD; P10601; 5 sequenced antibodies.
DR   DNASU; 19064; -.
DR   Ensembl; ENSMUST00000017460; ENSMUSP00000017460; ENSMUSG00000017316.
DR   Ensembl; ENSMUST00000170554; ENSMUSP00000126798; ENSMUSG00000017316.
DR   GeneID; 19064; -.
DR   KEGG; mmu:19064; -.
DR   UCSC; uc007lqm.1; mouse.
DR   CTD; 5539; -.
DR   MGI; MGI:97753; Ppy.
DR   VEuPathDB; HostDB:ENSMUSG00000017316; -.
DR   eggNOG; ENOG502TD4B; Eukaryota.
DR   GeneTree; ENSGT00530000064295; -.
DR   HOGENOM; CLU_165150_1_0_1; -.
DR   InParanoid; P10601; -.
DR   OMA; LGFLEWG; -.
DR   OrthoDB; 1586326at2759; -.
DR   PhylomeDB; P10601; -.
DR   TreeFam; TF332778; -.
DR   Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 19064; 3 hits in 71 CRISPR screens.
DR   PRO; PR:P10601; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P10601; protein.
DR   Bgee; ENSMUSG00000017316; Expressed in islet of Langerhans and 11 other tissues.
DR   ExpressionAtlas; P10601; baseline and differential.
DR   Genevisible; P10601; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IDA:MGI.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT   PEPTIDE         30..65
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000025368"
FT   PEPTIDE         69..100
FT                   /note="C-terminal peptide"
FT                   /id="PRO_0000025369"
FT   MOD_RES         65
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  11020 MW;  A0D0D04FB7DFB9D9 CRC64;
     MAVAYCCLSL FLVSTWVALL LQPLQGTWGA PLEPMYPGDY ATPEQMAQYE TQLRRYINTL
     TRPRYGKRAE EENTGGLPGV QLSPCTSPPV GLIPCSAPWS