PAHO_PIG
ID PAHO_PIG Reviewed; 65 AA.
AC P01300; Q9GKL0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Pancreatic prohormone precursor;
DE AltName: Full=Pancreatic polypeptide;
DE Short=PP;
DE Contains:
DE RecName: Full=Pancreatic hormone;
DE Short=PH;
DE Contains:
DE RecName: Full=Pancreatic icosapeptide;
DE Short=PI;
DE Flags: Precursor; Fragment;
GN Name=PPY;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE OF 1-36.
RA Chance R.E., Johnson M.G., Hoffmann J.A., Lin T.-M.;
RL (In) Baba S., Kaneko T., Yanaihara N. (eds.);
RL Proinsulin, insulin, c-peptide, pp.419-425, Excerpta Medica, Amsterdam
RL (1979).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-65, AND INDUCTION.
RX PubMed=11564690; DOI=10.1210/endo.142.10.8409;
RA Amaratunga A., Tuch B.E., Han X.-G., Georges P., Dean S.K., Scott H.;
RT "Secretion of pancreatic icosapeptide from porcine pancreas.";
RL Endocrinology 142:4314-4319(2001).
CC -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC functions.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- INDUCTION: Induced in hypoglycemia, and, in vitro, by carbocal, in
CC fetal pancreatic cells. {ECO:0000269|PubMed:11564690}.
CC -!- MISCELLANEOUS: May be used as a marker of the viability of
CC xenotransplanted fetal panreatic tissue in the immediate post-
CC transplant period.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR EMBL; AF203915; AAG35647.1; -; mRNA.
DR PIR; A01568; PCPG.
DR AlphaFoldDB; P01300; -.
DR SMR; P01300; -.
DR STRING; 9823.ENSSSCP00000018403; -.
DR PaxDb; P01300; -.
DR eggNOG; ENOG502TD4B; Eukaryota.
DR HOGENOM; CLU_165150_1_0_1; -.
DR InParanoid; P01300; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P01300; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR015480; Pancreatic_hormone.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW Secreted.
FT PEPTIDE 1..36
FT /note="Pancreatic hormone"
FT /id="PRO_0000025370"
FT PEPTIDE 40..58
FT /note="Pancreatic icosapeptide"
FT /id="PRO_0000025371"
FT PROPEP 59..>65
FT /id="PRO_0000292864"
FT MOD_RES 36
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 65
SQ SEQUENCE 65 AA; 7290 MW; 9CB8078F6247C0D7 CRC64;
APLEPVYPGD DATPEQMAQY AAELRRYINM LTRPRYGKRD EEDLLDLKCS SLHAAAPREL
SPMGA
