ID   PAHO_RAT                Reviewed;          98 AA.
AC   P06303;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE              Short=PH;
DE   Contains:
DE     RecName: Full=C-terminal peptide;
DE   Flags: Precursor;
GN   Name=Ppy;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3009446; DOI=10.1016/s0021-9258(19)84542-8;
RA   Yamamoto H., Nata K., Okamoto H.;
RT   "Mosaic evolution of prepropancreatic polypeptide.";
RL   J. Biol. Chem. 261:6156-6159(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3343236; DOI=10.1016/s0021-9258(18)69165-3;
RA   Yonekura H., Nata K., Watanabe T., Kurashina Y., Yamamoto H., Okamoto H.;
RT   "Mosaic evolution of prepropancreatic polypeptide. II. Structural
RT   conservation and divergence in pancreatic polypeptide gene.";
RL   J. Biol. Chem. 263:2990-2997(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3214179; DOI=10.1016/0003-9861(88)90083-5;
RA   Kopin A.S., Toder A.E., Leiter A.B.;
RT   "Different splice site utilization generates diversity between the rat and
RT   human pancreatic polypeptide precursors.";
RL   Arch. Biochem. Biophys. 267:742-748(1988).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: No icosapeptide-like peptide is cleaved from the C-terminal.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M13588; AAA41923.1; -; mRNA.
DR   EMBL; M18207; AAA41922.1; -; Genomic_DNA.
DR   EMBL; M27450; AAA99236.1; -; Genomic_DNA.
DR   PIR; A28261; PCRT.
DR   RefSeq; NP_036758.1; NM_012626.2.
DR   AlphaFoldDB; P06303; -.
DR   STRING; 10116.ENSRNOP00000028318; -.
DR   PaxDb; P06303; -.
DR   Ensembl; ENSRNOT00000028318; ENSRNOP00000028318; ENSRNOG00000020874.
DR   GeneID; 24677; -.
DR   KEGG; rno:24677; -.
DR   UCSC; RGD:3385; rat.
DR   CTD; 5539; -.
DR   RGD; 3385; Ppy.
DR   eggNOG; ENOG502TD4B; Eukaryota.
DR   GeneTree; ENSGT00530000064295; -.
DR   HOGENOM; CLU_165150_1_0_1; -.
DR   InParanoid; P06303; -.
DR   OMA; LGFLEWG; -.
DR   OrthoDB; 1586326at2759; -.
DR   PhylomeDB; P06303; -.
DR   TreeFam; TF332778; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P06303; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000020874; Expressed in pancreas and 6 other tissues.
DR   Genevisible; P06303; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT   PEPTIDE         30..65
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000025372"
FT   PEPTIDE         69..98
FT                   /note="C-terminal peptide"
FT                   /id="PRO_0000025373"
FT   MOD_RES         65
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10975 MW;  56AC03356D248FB0 CRC64;
     MAVAYYCLSL FLLSTWVALL LQPLQGAWGA PLEPMYPGDY ATHEQRAQYE TQLRRYINTL
     TRPRYGKRDE DTAGLPGRQL PPCTSLLVGL MPCAAARS