ID   PAHO_SHEEP              Reviewed;          78 AA.
AC   P01301; Q6T8R7;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Pancreatic prohormone;
DE   AltName: Full=Pancreatic polypeptide;
DE            Short=PP;
DE   Contains:
DE     RecName: Full=Pancreatic hormone;
DE              Short=PH;
DE   Contains:
DE     RecName: Full=Pancreatic icosapeptide;
DE              Short=PI;
DE   Flags: Precursor; Fragment;
GN   Name=PPY;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=15650129; DOI=10.1152/ajpregu.00494.2004;
RA   Limesand S.W., Jensen J., Hutton J.C., Hay W.W. Jr.;
RT   "Diminished beta-cell replication contributes to reduced beta-cell mass in
RT   fetal sheep with intrauterine growth restriction.";
RL   Am. J. Physiol. 288:R1297-R1305(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-55.
RA   Chance R.E., Moon N.E., Johnson M.G.;
RL   (In) Jaffe B.M., Behrman H.R. (eds.);
RL   Methods of hormone radioimmunoassay (2nd ed.), pp.657-672, Academic Press,
RL   New York and London (1979).
RN   [3]
RP   PROTEIN SEQUENCE OF 59-78.
RX   PubMed=6723953; DOI=10.1016/0014-5793(84)80265-3;
RA   Schwartz T.W., Hansen H.F.;
RT   "Isolation of ovine pancreatic icosapeptide: a peptide product containing
RT   one cysteine residue.";
RL   FEBS Lett. 168:293-298(1984).
CC   -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC       Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC       functions.
CC   -!- FUNCTION: The physiological role for the icosapeptide has not yet been
CC       elucidated.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AY427976; AAR11453.1; -; mRNA.
DR   PIR; B94465; PCSH.
DR   AlphaFoldDB; P01301; -.
DR   BMRB; P01301; -.
DR   SMR; P01301; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR015480; Pancreatic_hormone.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..19
FT                   /evidence="ECO:0000269|Ref.2"
FT   PEPTIDE         20..55
FT                   /note="Pancreatic hormone"
FT                   /id="PRO_0000025374"
FT   PEPTIDE         59..78
FT                   /note="Pancreatic icosapeptide"
FT                   /id="PRO_0000025375"
FT   MOD_RES         55
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         78
SQ   SEQUENCE   78 AA;  8573 MW;  5C055368029B4A97 CRC64;
     LLLSTCVALL LQPPLGALGA SLEPEYPGDN ATPEQMAQYA AELRRYINML TRPRYGKRDK
     EGTLDFLECG SPHSAVPR