PAHO_TAPPI
ID PAHO_TAPPI Reviewed; 36 AA.
AC P39659;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Pancreatic hormone;
DE Short=PH;
DE AltName: Full=Pancreatic polypeptide;
DE Short=PP;
GN Name=PPY;
OS Tapirus pinchaque (Mountain tapir).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Tapiridae; Tapirus.
OX NCBI_TaxID=30582;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC TISSUE=Pancreas;
RX PubMed=1808025; DOI=10.1016/0016-6480(91)90093-l;
RA Henry J.S., Lance V.A., Conlon J.M.;
RT "Primary structure of pancreatic polypeptide from four species of
RT Perissodactyla (Przewalski's horse, zebra, rhino, tapir).";
RL Gen. Comp. Endocrinol. 84:440-446(1991).
CC -!- FUNCTION: Pancreatic hormone is synthesized in pancreatic islets of
CC Langerhans and acts as a regulator of pancreatic and gastrointestinal
CC functions.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; C61132; C61132.
DR AlphaFoldDB; P39659; -.
DR BMRB; P39659; -.
DR SMR; P39659; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR015480; Pancreatic_hormone.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR PANTHER; PTHR10533:SF2; PTHR10533:SF2; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Hormone; Secreted.
FT PEPTIDE 1..36
FT /note="Pancreatic hormone"
FT /id="PRO_0000044802"
FT MOD_RES 36
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:1808025"
SQ SEQUENCE 36 AA; 4197 MW; 761B717671A6308F CRC64;
APLEPVYPGD NATPEQMAQY AAELRRYINM LTRPRY