ID   PAHX_CAEEL              Reviewed;         312 AA.
AC   O62515;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Probable phytanoyl-CoA dioxygenase;
DE            EC=1.14.11.18;
DE   AltName: Full=Phytanic acid oxidase;
DE   AltName: Full=Phytanoyl-CoA alpha-hydroxylase;
DE            Short=PhyH;
GN   ORFNames=ZK550.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA +
CC         CO2 + succinate; Xref=Rhea:RHEA:16065, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:57334, ChEBI:CHEBI:57391; EC=1.14.11.18;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000250};
CC   -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC   -!- SIMILARITY: Belongs to the PhyH family. {ECO:0000305}.
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DR   EMBL; Z82287; CAB05318.1; -; Genomic_DNA.
DR   EMBL; Z80223; CAB05318.1; JOINED; Genomic_DNA.
DR   PIR; T21397; T21397.
DR   RefSeq; NP_503062.1; NM_070661.3.
DR   AlphaFoldDB; O62515; -.
DR   SMR; O62515; -.
DR   BioGRID; 43579; 16.
DR   STRING; 6239.ZK550.6; -.
DR   EPD; O62515; -.
DR   PaxDb; O62515; -.
DR   PeptideAtlas; O62515; -.
DR   EnsemblMetazoa; ZK550.6.1; ZK550.6.1; WBGene00014000.
DR   GeneID; 178503; -.
DR   KEGG; cel:CELE_ZK550.6; -.
DR   UCSC; ZK550.6.1; c. elegans.
DR   CTD; 178503; -.
DR   WormBase; ZK550.6; CE20432; WBGene00014000; -.
DR   eggNOG; KOG3290; Eukaryota.
DR   GeneTree; ENSGT00390000001775; -.
DR   HOGENOM; CLU_060877_0_0_1; -.
DR   InParanoid; O62515; -.
DR   OMA; NRTEGFR; -.
DR   OrthoDB; 623398at2759; -.
DR   PhylomeDB; O62515; -.
DR   Reactome; R-CEL-389599; Alpha-oxidation of phytanate.
DR   UniPathway; UPA00199; -.
DR   PRO; PR:O62515; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00014000; Expressed in larva and 3 other tissues.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048244; F:phytanoyl-CoA dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0001561; P:fatty acid alpha-oxidation; IBA:GO_Central.
DR   InterPro; IPR008775; Phytyl_CoA_dOase.
DR   Pfam; PF05721; PhyH; 1.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome;
KW   Vitamin C.
FT   CHAIN           1..312
FT                   /note="Probable phytanoyl-CoA dioxygenase"
FT                   /id="PRO_0000215231"
FT   BINDING         84
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         124
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         142..144
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         144
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         231
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         233
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         242
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   312 AA;  35720 MW;  6B5A63624FCB70CB CRC64;
     MLGKGVVDYT REGSILSAEQ RRFYEKNGYL LIRNCVPQYE LNRFRQRFQD ICEKKVKAPE
     NMTVMKDISI AKSEFKDGEK AITKIQDFAD DPVLFEYCKY PGVVDVVKDL IGNPKSNLMA
     MHTMLINKPP DNGKLTSRHP MHQDLQYFPF RPADFICCAW TAMEKITRAN GCLVVVPGTH
     KGVLLPHEYP KWEGGVNKAY HGIQDYDTST PRIHVEMEPG DTVFFHPILI HGSGANRTEG
     FRKAISCHYA NDDLCRYVNV EGTTQETLAE EIIEIAKKRL TRYGLDPNTV TLDFADIWRV
     RAREVNGRRS NL